도움말

Ginseng Leaf Extract Prevents High Fat Diet-Induced Hyperglycemia and Hyperlipidemia through AMPK Activation

Journal of Ginseng Research Vol.34 No.4, 2010.12, 369-375 (7 pages)
인용정보 복사
Quick View Quick View
PDF View Text View
PDF Download
인용하기
이용수 : 114건
피인용수 : 0건
분야내 활용도 : 21%
자세히 보기 >

· 이용수 : 2010년부터 집계한 원문다운로드수

· 피인용수 : DBpia 논문 가운데 해당 논문을 인용한 논문수

· 분야내 활용도 : 최근 24개월간 DBpia 이용수를 기준으로 산출 / 0%에 가까울 수록 활용도가 높고, 100%에 가까울 수록 활용도가 낮음

초록
This study evaluated the protective effects of ginseng leaf extract (GLE) against high fat-diet-induced hyperglycemia and hyperlipidemia, and explored the potential mechanism underlying these effects in C57BL/6J mice. The mice were randomly divided into four groups: normal control, high fat diet control (HFD), GLE-treated at 250 ㎎/㎏, and GLE-treated at 500 ㎎/㎏. To induce hyperglycemic and hyperlipidemic states, mice were fed a high fat diet for 6 weeks and then administered GLE once daily for 8 weeks. At the end of the treatment, we examined the effects of GLE on plasma glucose, lipid levels, and the expression of genes related to lipogenesis, lipolysis, and gluconeogenesis. Both GLE groups lowered levels of plasma glucose, insulin, triglycerides, total cholesterol, and non-esterified fatty acids when compared to those in HFD group. Histological analysis revealed significantly fewer lipid droplets in the livers of GLE-treated mice compared with HFD mice. To elucidate the mechanism, Western blots and RT-PCR were performed using liver tissue. Compared with HFD mice, GLE-treated mice showed higher levels of phosphorylation of AMP-activated protein kinase (AMPK) and its substrate, acetyl-CoA carboxylase, but no differences in the expression of lipogenic genes such as sterol regulatory element-binding protein 1a, fatty acid synthase, sterol-CoA desaturase 1 and glycerol-3-phosphate acyltransferase. However, the expression levels of lipolysis and fatty acid uptake genes such as peroxisome proliferator-activated receptor-α and CD36 were increased. In addition, phospho-α and CD36 were increased. In addition, phosphoenolpyruvate carboxykinase gene expression was decreased. These results suggest that GLE ameliorates hyperglycemia and hyperlipidemia by inhibiting gluconeogenesis and stimulating lipolysis, respectively, via AMPK activation.

목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
키워드

논문의 주요 키워드를 제공합니다. 키워드를 클릭하여 관련 논문을 확인해 보세요!

참고문헌 (37)

현재 논문의 참고문헌을 찾아 신청해주세요!

  1. Kim YM , 2007 , Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3 I3 K, Akt-dependent ERK1, 2 and eNOS pathways in human umbilical vein endothelial cells , Biol Pharm Bull 30 : 1674 ~ 1679

  2. Tuttle KR , 2007 , PKC-DRS, PKC-DMES, and PKC-DRS 2 Study Groups. Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease , Clin J Am Soc Nephrol 2 : 631 ~ 636

  3. Zhiyong Liao , 2010 , Antidiabetic Effect of Flavones from Cirsium japonicum DC in Diabetic Rats , Archives of Pharmacal Research 33 (3) : 353 ~ 362

  4. Zhu CF , 2010 , Beneficial effects of oligopeptides from marine salmon skin in a rat model of type 2 diabetes , Nutrition 26 : 1014 ~ 1020

  5. Hamza N , 2010 , Prevention of type 2 diabetes induced by high fat diet in the C57BL, 6J mouse by two medicinal plants used in traditional treatment of diabetes in the east of Algeria , J Ethnopharmacol 128 : 513 ~ 518

  6. Stades AM , 2004 , Metformin and lactic acidosis: cause or coincidence? A review of case reports , J Intern Med 255 : 179 ~ 187

  7. Chiang CK , 2007 , Rosiglitazone in diabetes control in hemodialysis patients with and without viral hepatitis infection: effectiveness and side effects , Diabetes Care 30 : 3 ~ 7

  8. Kobayashi M , 2000 , Clinical evaluation of pioglitazone , Nippon Rinsho 58 : 395 ~ 400

  9. Ryu JK , 2005 , Free radical-scavenging activity of Korean red ginseng for erectile dysfunction in non-insulin-dependent diabetes mellitus rats , Urology 65 : 611 ~ 615

  10. Adiga S , 2010 , Hypoglycemic effect of aqueous extract of Trichosanthes dioica in normal and diabetic rats , Int J Diabetes Dev Ctries 30 : 38 ~ 42

  • 처음
  •  
  • 이전
  •  
  • 1
  •  
  • 2
  •  
  • 3
  •  
  • 4
  •  
  • 다음
  •  
  • 마지막
인용된 논문 (0)

알림서비스 신청하고 '인용된 논문' 정보를 메일로 확인 하세요!

해당 논문은 인용된 논문 정보가 없습니다.

제 1 저자의 다른 논문 (6)

Hai-Dan Yuan 식별저자 저자의 상세정보를 확인해 보세요.

권호 내 다른 논문 (17)

Journal of Ginseng Research Vol.34 No.4 의 상세정보를 확인해 보세요.

  • 처음
  •  
  • 이전
  •  
  • 1
  •  
  • 2
  •  
  • 다음
  •  
  • 마지막
추천 논문 (10)

DBpia 추천논문과 함께 다운받은 논문을 제공합니다. 논문 초록의 텍스트마이닝과 이용 및 인용 관계 분석을 통해 추천해 드리는 연관논문을 확인해보세요.

DBpia 추천논문

더 많은 추천논문을 확인해 보세요!

함께 다운받은 논문

지표

이용현황

· 이용수

· 이용순위 상위 Top3

자세히 보기 >
No 상위 이용이관 이용수
1 University of Virginia(버지니아 대학) 28
2 서울대학교 15
3 경북대학교 5

활용도

· 활용지수

· 논문의 활용도 추이 (주제분야 기준)

자세히 보기 >

: %

2016-09
2016-10
2016-11
2016-12
0
20
40
60
80
100
  • 0%
  • 20%
  • 40%
  • 60%
  • 80%
  • 100%

피인용수

상세정보
저작권 정책

누리미디어에서 제공되는 모든 저작물의 저작권은 원저작자에게 있으며, 누리미디어는 각 저작물의 내용을 보증하거나 책임을 지지 않습니다. 단, 누리미디어에서 제공되는 서지정보는 저작권법에 의해 보호를 받는 저작물로, 사전 허락 없이 임의로 대량 수집하거나 프로그램에 의한 주기적 수집 이용, 무단 전재, 배포하는 것을 금하며, 이를 위반할 경우, 저작권법 및 관련법령에 따라 민, 형사상의 책임을 질 수 있습니다.

맨 위로 이동