도움말

Role of fumarates in adaptogenics like efficacies of traditionally used Fumaria indica extracts

Anshul Shakya, Shyam Sunder Chatterjee, Vikas Kumar
Vol.5 No.1, 2015.02, 28-37 (10 pages)
Copy
Quick View
Not Available
You cannot read this article since the copyright contract has finished. It will be resumed as soon as possible.
Export
Usage : 24
Citations : 0
분야내 활용도 : 16%
More detail >

· Usage : Full-text article downdloads count since 2010.

· Citations : Cited in the DBpia's articles

· Impact Score : Calculates the article impact score on a basis of the usage in the last 24 months.

Abstract
Fumaria indica Linn. (Syn: Fumaria parviflora, Fumariaceae) is a wildly grown weed, mentioned and recommended in classical Ayurvedic texts for treatments of variety of ailments including dermatological diseases, topical diseases, cardiovascular complaints, circulatory disease, fever and headache etc. The present pilot study was designed to experimentally verify the possibility that fumarates are the major bioactive principles of Fumaria indica extracts involved in their stress response modulating activities, and to estimate pharmacologically active dose ranges of fumarates and standardized methanolic extract of Fumaria indica (MFI). Effect of single, 5 and 10 daily oral doses of pure fumaric acid (FA), monomethyl fumarate (MMF), dimethyl fumarate (DMF) and MFI was quantified in well validated rodent models viz. apomorphine induced cage climbing, stress induced hyperthermia, and elevated plus-maze tests. Obtained results reveal high efficacy of MFI and pure fumarates possess qualitatively analogous activity profiles in all the three tests. There were no significant difference in the potencies of pure FA, MMF and DMF in the three tests, whereas efficacy of MFI in the elevated plus maze test for anxiolytics was higher than in the other two tests. Efficacies of all the four test agents in all the three tests increased with increasing number of days of oral treatments. Results of these pilot experiments should be helpful for more rational selections of pharmacologically interesting dose ranges and treatment regimens of fumarates and Fumaria indica extracts for further more holistic explorations of their diverse therapeutic potentials.

TOC
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
Keyword

The Keywords of the article are provided. Click the keyword and check a related articles!

References (0)
Cited articles (0)

Please apply for Alerts and check the information by e-mail!

Cited articles not found.

Other articles of first author (0)

Other articles of first author not found.

Within this Journal (8)

Please check the detailed of Vol.5 No.1!

Recommended Articles (4)

We provide services, 'DBpia Recommended Articles' and 'Customers who used this article also used', that used text mining, usage and citations data.

DBpia Recommended Articles

DBpia Recommended Articles Articles not found.

Customers who used this article also used

Metrics

Usage Status

· Usage

· Top 3 institutions list on usage

More detail >
No Top institutions Usage
1 광운대학교 2
2 경희대학교 2
3 서울디지털대학교 1

Impact Score

· Impact Score

· The article impact score on the subject

More detail >

: %

2016-09
2016-10
2016-11
2016-12
0
20
40
60
80
100
  • 0%
  • 20%
  • 40%
  • 60%
  • 80%
  • 100%

Citations

Detailed Info
Copyright Policy

The copyright of all work are belongs to the original author. The contents of each work shall not be responsible or guarantee. Crawl the metadata of articles do not allowed without agreement.

top