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Inhibitory Effects of Ninety Nine Korean Plants on Human Immunodeficiency Virus Type 1 Protease Activity

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Inhibitory Effects of Ninety Nine Korean Plants on Human Immunodeficiency Virus Type 1 Protease Activity

Inhibitory Effects of Ninety Nine Korean Plants on Human Immunodeficiency Virus Type 1 Protease Activity

Jong Moon Hur Ju Gwon Park Jong Cheol Park Kyu Hawn Hyun Kab Yeon Lee Hirotsugu Miyashiro Masao Hattori

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초록

Ninety nine extracts from Korean plants were screened for their inhibitory activities on human immunodeficiency virus (HIV) type 1 protease by an HPLC method. The protease inhibitory activities were determined by incubating the extracts in reaction mixtures containing protease, substrate (His-Lys-Ala-Arg-Val-Leu-(p- NO₂-Phe)- Glu-Ala-Nle-Ser-NH₂) to perform proteolytic cleavage reactions. Of the extracts tested, the water extracts of Viburnum awabuki (stem, leaves), Distylium racemosum (leaves) had the highest protease inhibitory activities at a concentration of 100 μg/mL. Activity-guided fractionation, revealed that the n-butanol fraction of the V. awabuki extract, the ethyl acetate fraction from the D. racemosum extract had the greatest inhibitory activity on HIV-1 protease.

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Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS AND DISCUSSION

ACKNOWLEDGEMENTS

REFERENCES

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