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Apoptosis of MCF7 Cells Treated with PKC Inhibitors and Daunorubicin

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Apoptosis of MCF7 Cells Treated with PKC Inhibitors and Daunorubicin

Apoptosis of MCF7 Cells Treated with PKC Inhibitors and Daunorubicin

Joo Young Son Sook-Hyun Chung Won Gun An Won Chul Choi

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초록

The present study was performed to observe the role of protein kinase C (PKC) inhibitors (H-7, staurosporine), daunorubicin in the cell death process of MCF7 cells;, examined whether or not the type of induced cell death was apoptosis. The usefulness of the combined therapy of PKC inhibitors, daunorubicin to improve the adverse effect of daunorubicin was also investigated. Cell death was induced by treatment with PKC inhibitors or daunorubicin. Characteristic morphologic features of cell shrinkage, chromatin condensation,, cytoplasmic vacuolization were observed. These treatments also stimulated the cleavage of poly-(ADP-ribose) polymerase (PARP), an early event in apoptosis. With slight differences in the percentage of apoptosis-induced cells, staurosporine, H-7, daunorubicin effectively induced apoptosis in MCF7 cells. Furthermore, combined treatment of PKC inhibitors, daunorubicin significantly drove the cells into an apoptotic state. Hence, our results revealed the possible therapeutic value of combined therapy for the prevention of drug resistance, adverse side effects.

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Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENTS

REFERENCES

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