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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.9
- 수록면
- 241 - 248 (8page)
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초록· 키워드
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The present study was conducted to investigate the potential subacute toxicity of CJ-10882 by a 4-week repeated oral does in dogs. The test article was administered once daily by gavage to dogs at dose levels of 0, 2, 10, and 50 mg/kg/day for 4 weeks. During the test period, clinical signs, mortality, body weights, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross finding, organ weight, and histopathology were evaluated. Several clinical signs were observed in treated dogs at 50 mg/kg, including salivation and vomiting. Increase in the serum levels of ALT and albumin observed in the female 50 mg/kg group was considered as a toxic effect related to the test article since the histopatho-logical change in liver was accompanied. There were no treatment-related effects on mortality, food and water consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, necropsy findings and organ weights in any treatment group. Based on these results, target organ was not observed and the no-observed-adverse-effect level (NOAEL) was 10 mg/kg/day and the absolute toxic dose was 50 mg/kg for both male and female dogs.
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UCI(KEPA) : I410-ECN-0101-2009-513-013456474