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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 421 - 428 (8page)
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초록· 키워드
오류제보하기
Iron is essential for life and has numerous biochemical roles. Phytic acid (PA) has been recognized as a natural antioxidant by its chelating properties and reducing the catalytic activities of many divalent transition metals. We investigated the effect of PA on the formation of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in dietary iron-deficient F344 rats. After acclimation for one week, six-week old F344 male rats were fed with the AIN-93G purified diet (normal diet) or an iron-deficient diet (3 ppm Fe, only 10% vs control diet) for 8 weeks. PA (0.5% or 2% PA in water) was given for drink throughout the experimental period. Animals were treated subcutaneously with AOM (15 ㎎/㎏) twice (1<SUP>st</SUP> and 2<SUP>nd</SUP> week of the experiment) to induce colonic ACF. After sacrifice, the colonic mucosa were examined for the total numbers of aberrant crypt (AC) and ACF after staining with methylene blue. The blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. Iron-deficient diet induced an anemic status of rats as indicated by significantly low values in RBC count, hemoglobin, hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin, compared with the AOMtreated control (P＜0.01). However, treatments of PA increased these values. Treatment with 2% PA significantly increased the numbers of both ACF/colon and AC/colon in iron deficient rats, compared with the respective control (P＜0.05). The number of large ACF (≥4 AC/ACF), which had been suggested to possess a greater tumorogenic potential than small ACF (≤3 AC/ACF), was significantly enhanced by treatment with 2% PA (P＜0.05). These results suggest that PA may promote colon carcinogenesis in irondeficient status in rats.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (42)
참고문헌 신청
1. [학술지(정기간행물)] - Babbs, C.F. / 1990 / Free radicals and the etiology of colon cancer / Free Radic. Biol. Med 8 : 191 ~ 200
2. [학술지(정기간행물)] - Babbs, C.F. / 1992 / Oxygen radicals in ulcerative colitis / Free radic. Biol. Med 13 : 169 ~ 181
3. [학술지(정기간행물)] - Baten, A. / 1989 / Inositol-phosphate-induced enhancement of natural killer cell activity correlates with tumor suppression / Carcinogenesis 10 : 1595 ~ 1598
4. [학술지(정기간행물)] - Bird, R.P. / 1987 / Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings / Cancer Lett 137 : 147 ~ 151
5. [학술지(정기간행물)] - Challa, A. / 1997 / Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea / Carcinogenesis 182 : 2023 ~ 2026
2. [학술지(정기간행물)] - Babbs, C.F. / 1992 / Oxygen radicals in ulcerative colitis / Free radic. Biol. Med 13 : 169 ~ 181
3. [학술지(정기간행물)] - Baten, A. / 1989 / Inositol-phosphate-induced enhancement of natural killer cell activity correlates with tumor suppression / Carcinogenesis 10 : 1595 ~ 1598
4. [학술지(정기간행물)] - Bird, R.P. / 1987 / Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings / Cancer Lett 137 : 147 ~ 151
5. [학술지(정기간행물)] - Challa, A. / 1997 / Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea / Carcinogenesis 182 : 2023 ~ 2026
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