지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 195 - 200 (6page)
이용수
초록· 키워드
오류제보하기
Hydroxylated polychlorinated biphenyl (OH-PCBs)는 PCB의 CYP-dependent oxidation의 대사물로서 잠재적 독성이 강하고 지질친화성을 가지며 생물군에 지속적인 축적성을 나타낸다. OH-PCBs의 해독화 효능을 조사하기 위하여 channel catfish 간에서 glucuronidation을 통한 해독작용 가능성을 평가하고 biphenyl 구조에 다양한 염소치환의 구조적 차이점에 따른 영향을 비교 분석하여 보았다. Kinetic parameters에서 Km과 V<SUB>max</SUB>는 192~871 μM, 869~1774 pmol/min/mg으로써 4′-OH-PCB35와 4′-OHPCB69이 가장 높은 속도의 glucuronidation을 나타냈으며, 구조적 차이점에서 phenolic group에 한 개의 염소치환이 존재할 경우보다 두 개의 염소치환이 존재할 경우에 OH-PCBs (p＜0.001)의 glucuronidation에 대한 V<SUB>max</SUB>를 현저하게 낮추는 결과를 보였다.
목차
요약
INTRODUCTION
MATERIALS AND METHEDS
RESULTS AND DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (20)
참고문헌 신청
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2. [학술지(정기간행물)] - Bergman A / 1994 / Selective retention of hydroxylated PCB metabolites in blood / Environmental Health Perspectives 102 : 464 ~ 469
3. [학술지(정기간행물)] - Brouwer A / 1986 / Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin / Toxicology and Applied Pharmacology 85 : 301 ~ 312
4. [학술지(정기간행물)] - Brouwer A / 1998 / Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health / Toxicology and Industrial Health 14 : 59 ~ 84
5. [학술지(정기간행물)] - Connor K / 1997 / Hydroxylated polychlorinated biphenyls (PCBs)as estrogens and antiestrogens: structure-activity relationships / Toxicology and Applied Pharmacology 14 : 111 ~ 123
2. [학술지(정기간행물)] - Bergman A / 1994 / Selective retention of hydroxylated PCB metabolites in blood / Environmental Health Perspectives 102 : 464 ~ 469
3. [학술지(정기간행물)] - Brouwer A / 1986 / Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin / Toxicology and Applied Pharmacology 85 : 301 ~ 312
4. [학술지(정기간행물)] - Brouwer A / 1998 / Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health / Toxicology and Industrial Health 14 : 59 ~ 84
5. [학술지(정기간행물)] - Connor K / 1997 / Hydroxylated polychlorinated biphenyls (PCBs)as estrogens and antiestrogens: structure-activity relationships / Toxicology and Applied Pharmacology 14 : 111 ~ 123
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The effect of PCBs (polychlorinated biphenyls) on EROD activity In vivo.
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Bioaccumulation of Polychlorinated Biphenyls in sea urchins exposed to contaminated sediments
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Biomonitoring of polychlorinated biphenyls using pine needle and Mongolian oak leaf: seasonal variation and congener pattern
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Polychlorinated Biphenyl에 의한 백서간 Cytochrome P-$450_{LMII}$에 대한 Monoclonal Antibody 생성에 관한 연구
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소수성 유기오염물질의 해수와 용존유기탄소 사이의 분배 특성
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