지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 759 - 765 (7page)
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This study was performed to investigate improvements in diabetes mellitus by extracts of yacon in streptozotocin (STZ)-induced diabetic rats. Fifty rats were divided into a normal group and four experimental groups. STZ (45 ㎎/㎏) was injected intraperitoneally to induce type I diabetes in the four experimental groups. Yacon extracts were administered for 5 weeks. Forty-five ICR mice were also divided into one positive control group and four experimental groups for the oral glucose tolerance test (OGTT) after fed yacon extract. The control group did not eat any yacon extracts, while Group 1 (GI) was fed 125 ㎎/㎏ of yacon extracts, Group 2 (GII) was fed 250 ㎎/㎏ of yacon extracts, and Group 3 (GIII) was fed 500 ㎎/㎏ of yacon extracts. After treatment for 5 weeks, blood glucose in GIII group showed decreased tendency at the 5 week. In OGTT by glucose, the glucose level of yacon treatment group in diabetic rats was significantly decreased compared to the glucose level of the control group, but there was no difference in OGTT by maltose. In ICR mice, the glucose level of the experimental group in OGTT by maltose was significantly decreased compared to the control group. The area of the islets of Langerhans was increased by yacon treatment in a dose-dependent manner on diabetic rats. Insulin concentration of the GIII group was also decreased compared to the control group, while the concentration of fructosamine, total cholesterol, and triglycerides in serum showed no difference. OGTT by glucose or maltose in ICR mice or diabetic rats, area of the Islets of Langerhans, and insulin concentration improved. Yacon treatment may be a useful therapeutic and preventive strategy for diabetes mellitus.
목차
Abstract
서론
재료 및 방법
결과 및 고찰
요약
감사의 글
문헌
참고문헌 (30)
참고문헌 신청
Kim HY / 1992 / Nutrition state and immunity ability / Kor J Nutr 25:312~320
DeFronzo RA / 1992 / Pathogenesis of NIDDM: a balanced overview / Diabetes Care 15:318~368
Vinik A / 1996 / Determinants of pancreatic islet cell mass: a balancebetween neogenesis and senescence/apoptosis / Diabetes Rev 4:235~263
Poitout V / 1996 / Chronic exposure of βTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator / J Clin Invest 97:1041~1046
Moran A / 1997 / Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HITT15 / J Clin Invest 99:534~539
DeFronzo RA / 1992 / Pathogenesis of NIDDM: a balanced overview / Diabetes Care 15:318~368
Vinik A / 1996 / Determinants of pancreatic islet cell mass: a balancebetween neogenesis and senescence/apoptosis / Diabetes Rev 4:235~263
Poitout V / 1996 / Chronic exposure of βTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator / J Clin Invest 97:1041~1046
Moran A / 1997 / Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HITT15 / J Clin Invest 99:534~539
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UCI(KEPA) : I410-ECN-0101-2013-511-002704084