결장 및 직장암 환자에서 혈청과 면역조직화학 염색에서 CA19-9의 의의

김민수; 주호민; 홍성우; 강윤경; 천정우; 장여구; 백인욱; 이혁상

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자료유형: 학술저널

저자정보: 김민수 (인제대학교) 주호민 (인제대학교) 홍성우 (인제대학교) 강윤경 (인제대학교) 천정우 (인제대학교) 장여구 (인제대학교) 백인욱 (인제대학교) 이혁상 (인제대학교)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research 대한외과학회지 Vol.75 No.5

발행연도: 2008.11

수록면: 307 - 314 (8page)

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Purpose: There has been much debate about the significance of the CA19-9 level for predicting the prognosis of colorectal cancer patients. This study aimed to evaluate the prognostic value of the preoperative serum CA19-9 level and the CA19-9 expression in the tumor tissues of colorectal cancer patients
Methods: One hundred patients with colorectal cancer and who had been treated by resection were studied. We assessed the correlations of the preoperative serum CA19-9 level and the status of the CA19-9 immunohistochemical staining with the clinicopathologic features, including the prognosis of the patients.
Results: The preoperative serum CA19-9 level had significant correlation with the status of CA19-9 immunohistochemical staining. The presence of distant metastasis was significantly correlated with an elevated level of serum CA19-9. The depth of tumor, the presence of lymph node metastasis, the TNM stage and tumor cell differentiation were significantly correlated with the status of the CA19-9 immunohistochemical staining. In addition, the gross morphology, depth of tumor, the presence of lymph node metastasis, the TNM stage, the status of the CA19-9 immunohistochemical staining and the serum CEA level were correlated with survival on univariate analysis. However, multivariate analysis did not validate the status of CA19-9 immunohistochemical staining as a significantly independent predictor of the prognosis.
Conclusion: The CA19-9 expression was frequently observed in advanced stage tumor tissue, yet its expression in tumor tissue or the preoperative CA19-9 serum level did not show independent prognostic value for colorectal cancer patients.

#Colorectal cancer #CA19-9 expression #Immunohistochemical stain #Clinicopathologic feature #Prognostic indicator #결장 및 직장암 #CA19-9의 발현 #면역조직화학염색 #임상병리학적 소견 #예후인자

참고문헌 (22)

참고문헌 신청

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2. [학술지(정기간행물)] - Koprowski H / 1979 / Colorectal carcinoma antigens detected by hybridoma antibodies / Somat Cell Genet 5 : 957 ~ 972

3. [학술지(정기간행물)] - Berg EL / 1992 / Comparison of L-selectin and E-selectin ligand specificities / Biochem Biophys Res Commun 184 : 1048 ~ 1055

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5. [학술지(정기간행물)] - Nakagoe T / 2003 / Preoperative serum level of CA19-9 predicts recurrence after curative surgery in node negative colorectal cancer patients / Hepatogastroenterology 50 : 696 ~ 699

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