지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.83 No.4
- 발행연도
- 2012.10
- 수록면
- 187 - 195 (9page)
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Purpose: The genes p53 and B-cell lymphoma (bcl)-2 play an important role in regulating the mechanisms of apoptosis. In this paper, we retrospectively applied these factors to our series of triple negative breast cancer (TNBC) patients, in conjunction with an evaluation of the prognostic significance of these factors’ influence on TNBC survival rate. Particular focus was placed on the role of bcl-2, p53, Ki-67. Methods: The study subjects, 94 women with TNBC, were a subset of patients operated at Kosin University Gospel Hospital from January 2000 to December 2005. Chi-squared tests were used for statistical analysis. Results: Positive staining for cytokeratin (CK)5/6 in 23 cases (24.5%), epidermal growth factor receptor in 15 cases (16.0%), bcl-2 in 26 cases (27.7%), p53 in 55 cases (58.5%) and Ki-67 in 74 cases (78.7%) was determined. Lymph node status, tumor size and expression of CK5/6 or Ki-67 were independent prognostic factors for patients with TNBC. Conclusion: Markers regulating cell cycle and cell death such as p53 and bcl-2 cannot be used to classify TNBCs into two subtypes with differing disease-free survival. But because our study is small in size, more abundant patient data will be needed to evaluate the factors’ predictive role in regulating cell cycle and cell death.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Nakagawa M / 2011 / Expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A in triple-negative breast cancer / Anticancer Res 31 : 2389 ~ 2393
2. [학술지(정기간행물)] - Elnashar AT / 2012 / The prognostic value of triple negative in stage II/III breast cancer / J Oncol Pharm Pract 18 : 68 ~ 75
3. [학술지(정기간행물)] - Yerushalmi R / 2012 / Tumor markers in metastatic breast cancer subtypes: frequency of elevation and correlation with outcome / Ann Oncol 23 : 338 ~ 345
4. [학술지(정기간행물)] - Montagna E / 2012 / Breast cancer subtypes and outcome after local and regional relapse / Ann Oncol 23 : 324 ~ 331
5. [학술지(정기간행물)] - Skarlos P / 2012 / Triple-negative phenotype is of adverse prognostic value in patients treated with dose- dense sequential adjuvant chemotherapy: a translational research analysis in the context of a Hellenic Cooperative Oncology Group (HeCOG) randomized phase III trial / Cancer Chemother Pharmacol 69 : 533 ~ 546
2. [학술지(정기간행물)] - Elnashar AT / 2012 / The prognostic value of triple negative in stage II/III breast cancer / J Oncol Pharm Pract 18 : 68 ~ 75
3. [학술지(정기간행물)] - Yerushalmi R / 2012 / Tumor markers in metastatic breast cancer subtypes: frequency of elevation and correlation with outcome / Ann Oncol 23 : 338 ~ 345
4. [학술지(정기간행물)] - Montagna E / 2012 / Breast cancer subtypes and outcome after local and regional relapse / Ann Oncol 23 : 324 ~ 331
5. [학술지(정기간행물)] - Skarlos P / 2012 / Triple-negative phenotype is of adverse prognostic value in patients treated with dose- dense sequential adjuvant chemotherapy: a translational research analysis in the context of a Hellenic Cooperative Oncology Group (HeCOG) randomized phase III trial / Cancer Chemother Pharmacol 69 : 533 ~ 546
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UCI(KEPA) : I410-ECN-0101-2014-514-001420044