Performance characteristics according to fiber direction of anisotropic Gas Diffusion Layer(GDL) has been numerically investigated. To analyze the characteristics accurately, different GDL properties(as porosity, diffusivity and permeability) under rib/channel by non-uniform compression is defined when mesh grid is generated. Simulation results explain that performances of fuel cell with 90˚ GDL are generally higher than those with 0˚ GDL, because saturation water distribution is lower in 90˚ GDL by higher permeability and porosity compared with 0˚ GDL. The results mean anisotropic characteristics of GDL can play import role in water management and cell performance.