지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.2
- 수록면
- 33 - 40 (8page)
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초록· 키워드
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Anti-diabetic effect of the exopolysaccharides (EPS) produced from submerged mycelial culture of Cordyceps sinensis (Cs) was studiedin a type II diabetic animal model (C57BL/6J ob/ob). This study was designed to determine whether Cs-EPS improves clinical symptoms of type II diabetes in ob/ob mice. After Cs-EPS treatment at doses of 200 mg/kg body weight, the fasting blood glucose levels decreased by 47% after 7 weeks compared with those of the control mice. According to the oral glucose tolerance test, the glucose levels recovered its baseline after 120 min in Cs-EPS-treated mice, although the blood glucose levels increased significantly after 30 min. On the other hand, the control group (not-treated) did not recovered its initial level of glucose after 120 min. Furthermore, food intake, body weight, total plasma cholesterol and triglyceride concentrations in ob/ob mice treated with Cs-EPS were significantly decreased, compared with those in control ob/ob mice. Cs-EPS treatment increased significantly the plasma insulin level and the expression of leptin mRNA in adipose tissue of Cs-EPS-treated ob/ob mice. From these results, it is demonstrated that Cs-EPS could be effective for regulating normal blood glucose levels by increasing the amounts of plasma insulin and leptin expression in ob/ob mice, indicating that this compound could be a candidate material as a dietary supplement to control hyperglycemia in patients suffering from type II diabetes.
목차
Abstract
1. Introduction
2. Materials andMethods
3. Results and Discussion
References
참고문헌 (53)
참고문헌 신청
1. [학술지(정기간행물)] - Zimmet, P / 2001 / Global and societal implications of the diabetes epidemic / Nature 414 : 782 ~ 787
2. [단행본] - Polonsky, K. S / 1996 / Non-insulindependent diabetes mellitus a genetically programmed failure of the beta cell to compensate for insulin resistance / New Engl. J. Med : 777 ~ 783
3. [학술지(정기간행물)] - Taylor, S. I / 1999 / Deconstructing type 2 diabetes / Cell 97 : 9 ~ 12
4. [단행본] - Holman, R. R / 1991 / Oral agents and insulin in the treatment of NIDDM. in Text book of Diabetes / Blackwell Scientific Publication
5. [학술지(정기간행물)] - Cho, E. J / 2007 / Hypoglycemic effects of exopolysaccharides produced by mycelia cultures of two different mushrooms Tremella fuciformis and Phellinus baumii in ob/ob mice / Appl. Micribiol. Biotechnol 75 : 1257 ~ 1265
2. [단행본] - Polonsky, K. S / 1996 / Non-insulindependent diabetes mellitus a genetically programmed failure of the beta cell to compensate for insulin resistance / New Engl. J. Med : 777 ~ 783
3. [학술지(정기간행물)] - Taylor, S. I / 1999 / Deconstructing type 2 diabetes / Cell 97 : 9 ~ 12
4. [단행본] - Holman, R. R / 1991 / Oral agents and insulin in the treatment of NIDDM. in Text book of Diabetes / Blackwell Scientific Publication
5. [학술지(정기간행물)] - Cho, E. J / 2007 / Hypoglycemic effects of exopolysaccharides produced by mycelia cultures of two different mushrooms Tremella fuciformis and Phellinus baumii in ob/ob mice / Appl. Micribiol. Biotechnol 75 : 1257 ~ 1265
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UCI(KEPA) : I410-ECN-0101-2014-400-002396271