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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.89 No.4
- 발행연도
- 2015.9
- 수록면
- 208 - 214 (7page)
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초록· 키워드
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Purpose: The purpose of this study was to analyze the risk factors for delayed graft function (DGF) and determine its impact on the outcomes of deceased donor (DD) kidney transplantation (KT).
Methods: Between January 2000 and December 2011, we performed 195 DD renal transplants. After the exclusion of primary nonfunctional grafts (n = 4), the study recipients were divided into two groups?group I, DGF (n = 31, 16.2%); group II, non-DGF (n = 160, 83.8%). The following variables were compared: donor and recipient characteristics, patient and graft survival, postoperative renal function, acute rejection (AR) episodes, and the rates of surgical and infectious complications.
Results: Donor-related variables that showed significant differences included hypertension (P = 0.042), diabetes (P = 0.025), and prerecovery serum creatinine levels (P < 0.001). However, there were no significant differences in recipientrelated factors. One significantly different transplant-related factor was positive panel reactive antibody (PRA > 20%, P = 0.008). On multivariate analysis, only the prerecovery serum creatinine level (P < 0.001; hazard ratio [HR], 1.814) was an independent risk factor for the development of DGF. A Cox multivariate analysis of risk factors for graft survival identified these independent risk factors for graft survival: nephron mass (donor kidney weight to recipient body weight ratio) index (P = 0.026; HR, 2.328), CMV infection (P = 0.038; HR, 0.114), and AR episode (P = 0.038; HR, 0.166).
Conclusion: In DD KT, an independent risk factor for DGF was the prerecovery serum creatinine level. Although there was a significant difference in graft survival between the DGF and non-DGF groups, DGF was not an independent risk factor for graft failure in this study.
Methods: Between January 2000 and December 2011, we performed 195 DD renal transplants. After the exclusion of primary nonfunctional grafts (n = 4), the study recipients were divided into two groups?group I, DGF (n = 31, 16.2%); group II, non-DGF (n = 160, 83.8%). The following variables were compared: donor and recipient characteristics, patient and graft survival, postoperative renal function, acute rejection (AR) episodes, and the rates of surgical and infectious complications.
Results: Donor-related variables that showed significant differences included hypertension (P = 0.042), diabetes (P = 0.025), and prerecovery serum creatinine levels (P < 0.001). However, there were no significant differences in recipientrelated factors. One significantly different transplant-related factor was positive panel reactive antibody (PRA > 20%, P = 0.008). On multivariate analysis, only the prerecovery serum creatinine level (P < 0.001; hazard ratio [HR], 1.814) was an independent risk factor for the development of DGF. A Cox multivariate analysis of risk factors for graft survival identified these independent risk factors for graft survival: nephron mass (donor kidney weight to recipient body weight ratio) index (P = 0.026; HR, 2.328), CMV infection (P = 0.038; HR, 0.114), and AR episode (P = 0.038; HR, 0.166).
Conclusion: In DD KT, an independent risk factor for DGF was the prerecovery serum creatinine level. Although there was a significant difference in graft survival between the DGF and non-DGF groups, DGF was not an independent risk factor for graft failure in this study.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Koning OH. / 1997 / Risk factors for delayed graft function in cadaveric kidney transplantation : a prospective study of renal function and graft survival after preservation with University of Wisconsin solution in multiorgan donors. European Multicenter Study Group / Transplantation 63 : 1620 ~ 1628
[학술지(정기간행물)] - Ojo AO. / 1997 / Delayed graft function : risk factors and implications for renal allograft survival / Transplantation 63 : 968 ~ 974
[학술지(정기간행물)] - Yarlagadda SG. / 2008 / Marked variation in the definition and diagnosis of delayed graft function : a systematic review / Nephrol Dial Transplant 23 : 2995 ~ 3003
[학술지(정기간행물)] - Miglinas M. / 2013 / Delayed graft function : risk factors and the effects of early function and graft survival / Transplant Proc 45 : 1363 ~ 1367
[학술지(정기간행물)] - Grosso G. / 2012 / Delayed graft function and long-term outcome in kidney transplantation / Transplant Proc 44 : 1879 ~ 1883
[학술지(정기간행물)] - Ojo AO. / 1997 / Delayed graft function : risk factors and implications for renal allograft survival / Transplantation 63 : 968 ~ 974
[학술지(정기간행물)] - Yarlagadda SG. / 2008 / Marked variation in the definition and diagnosis of delayed graft function : a systematic review / Nephrol Dial Transplant 23 : 2995 ~ 3003
[학술지(정기간행물)] - Miglinas M. / 2013 / Delayed graft function : risk factors and the effects of early function and graft survival / Transplant Proc 45 : 1363 ~ 1367
[학술지(정기간행물)] - Grosso G. / 2012 / Delayed graft function and long-term outcome in kidney transplantation / Transplant Proc 44 : 1879 ~ 1883
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UCI(KEPA) : I410-ECN-0101-2016-514-002004148