Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid ymphoma : a multicenter study :a multicenter study

Young Jun Chai; Jun Hyun Hong; Do Hoon Koo; Hyeong Won Yu; Joon-Hyop Lee; Hyungju Kwon; Su-jin Kim; June Young Choi; Kyu Eun Lee

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저자정보: Young Jun Chai (Seoul National University Boramae Medical Center) Jun Hyun Hong (Seoul National University College of Medicine) Do Hoon Koo (Inje University College of Medicine) Hyeong Won Yu (Seoul National University College of Medicine) Joon-Hyop Lee (Seoul National University College of Medicine) Hyungju Kwon (Seoul National University College of Medicine) Su-jin Kim (Seoul National University College of Medicine) June Young Choi (Seoul National University College of Medicine) Kyu Eun Lee (Seoul National University College of Medicine)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.89 No.6

발행연도: 2015.11

수록면: 295 - 299 (5page)

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Purpose: Primary thyroid lymphoma (PTL) is a rare disease and it has been investigated in a limited number of studies. The present multicenter study evaluated the clinical features and treatment outcomes of PTL.
Methods: The medical records of patients diagnosed with PTL between 2000 and 2013 in three centers were retrospectively reviewed.
Results: The study included 11 men and 27 women with a median age of 63.3 years (range, 42–83 years). The median follow-up was 56.0 months (range, 3–156 months). Of the 38 patients included, 16 had mucosa-associated lymphoid tissue (MALT) lymphoma, six had mixed MALT and diffuse large B-cell lymphoma (DLBCL), and 16 had DLBCL. Thirty-five patients (92.1%) had early stage (stage I/II) disease. Of the 16 MALT lymphoma patients, 14 were treated by surgery, and radiotherapy (RT) or chemotherapy was combined in five patients. Two patients received RT or chemotherapy alone. Of the six mixed MALT and DLBCL patients, three underwent surgery with chemotherapy and three underwent chemotherapy alone, RT alone, or surgery with RT. All of the 16 DLBCL patients received chemotherapy, and surgery and RT was combined in 4 and 1 patients, respectively. The 5-year survival was 100% for MALT lymphoma (7 of 7) and mixed MALT and DLBCL patients (5 of 5) and 87.5% for DLBCL patients (7 of 8).
Conclusion: Early stage PTL has an excellent prognosis when managed by single or combined treatment modalities. Clinicians should consider PTL in patients with underlying Hashimoto’s thyroiditis presenting with an enlarging thyroid mass.

#Lymphoma #Thyroid lymphoma #Primary thyroid lymphoma #Marginal zone B-cell lymphoma #Diffuse Large B-cell lymphoma

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