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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.7
- 수록면
- 239 - 243 (5page)
이용수
초록· 키워드
오류제보하기
Propolis is a multicomponent, active, complex resinous substance collected by honeybees from a variety of plant sources. We have studied the effect of propolis on neurite outgrowth of SH-SY5Y human neuroblastoma cells induced to differentiate by all-trans-retinoic acid (RA). Propolis, at a concentration of 3 μg/mL, had no significant effect on the viability of differentiating SH-SY5Y cells. However, the neurite outgrowth of the differentiating SH-SY5Y cells treated with propolis (0.3~3 μg/mL) for 48 hr was significantly inhibited in a dose-dependent manner. Treatment of RA-stimulated differentiating SH-SY5Y cells with 0.3 to 3 μg/mL propolis resulted in decreased level of transglutaminase and 43-kDa growth-associated protein (GAP-43) in a dose-dependent manner. The results indicate that propolis is able to inhibit neurite outgrowth of differentiating SH-SY5Y cells.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULT
DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
Drago, B / 2000 / In vitro antimicrobial activity of propolis dry extract / J. Chemother 12:390~395
Mizoeva, O. K / 1996 / The effect of propolis and its components on eicosanoid production during the inflammatory response / Prostaglandins Leukot. Essent. Fatty Acids 55:441~449
Krol, W / 1990 / Anti-oxidant property of ethanolic extract of propolis(EEP)as evaluated by inhibiting the chemiluminescence oxidation of luminal / Biochem. Int 21:593~597
Scheller, S / 1990 / Free radical scavenging by ethanol extract of propolis / Int. J. Radiat. Biol 57:461~465
Chen, S. N / 2004 / Comparison of radical scavenging activity, cytotoxic effects and apoptosis induction in human melanoma cells by Taiwanese propolis from different sources / Evid. Based Complement. Alternat. Med 1:175~185
Mizoeva, O. K / 1996 / The effect of propolis and its components on eicosanoid production during the inflammatory response / Prostaglandins Leukot. Essent. Fatty Acids 55:441~449
Krol, W / 1990 / Anti-oxidant property of ethanolic extract of propolis(EEP)as evaluated by inhibiting the chemiluminescence oxidation of luminal / Biochem. Int 21:593~597
Scheller, S / 1990 / Free radical scavenging by ethanol extract of propolis / Int. J. Radiat. Biol 57:461~465
Chen, S. N / 2004 / Comparison of radical scavenging activity, cytotoxic effects and apoptosis induction in human melanoma cells by Taiwanese propolis from different sources / Evid. Based Complement. Alternat. Med 1:175~185
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UCI(KEPA) : I410-ECN-0101-2017-513-000816774