지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.91 No.3
- 발행연도
- 2016.9
- 수록면
- 118 - 126 (9page)
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초록· 키워드
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Purpose: The selection of the appropriate treatment strategy for patients with mucosal gastric cancer (MGC) remains controversial. In the present study, we aimed to determine the risk factors for lymph node (LN) metastasis in MGC and reassess the role of endoscopic submucosal dissection (ESD).
Methods: We examined 1,191 MGC patients who underwent curative gastrectomy between January 2005 and December 2014. We determined the clinicopathologic risk factors for LN metastasis among the MGC patients.
Results: Among 1,191 patients with MGC, 42 patients (3.5%) had LN metastasis. Univariate analysis indicated that age ≤ 50 years (P = 0.045), tumor invasion to the muscularis mucosa (P < 0.001), tumor size > 2 cm (P = 0.014), presence of ulceration (P = 0.01), diffuse type as per Lauren classification (P = 0.005), and undifferentiated-type histology (P = 0.001) were associated with LN metastasis. Moreover, multivariate analysis indicated that tumor invasion to the muscularis mucosa (P = 0.001; odds ratio [OR], 4.909), presence of ulceration (P = 0.036; OR, 1.982), and undifferentiated-type histology (P = 0.025; OR, 4.233) were independent risk factors for LN metastasis. In particular, LN metastasis was observed in some MGC cases with indications for ESD, including absolute indications (1 of 179, 0.6%) and expanded indications (9 of 493, 1.8%).
Conclusion: Although MGC patients can be treated via ESD, we recommend that they undergo a more aggressive treatment strategy if they have tumor invasion to the muscularis mucosa, ulceration, or undifferentiated-type histology in the final pathology report.
Methods: We examined 1,191 MGC patients who underwent curative gastrectomy between January 2005 and December 2014. We determined the clinicopathologic risk factors for LN metastasis among the MGC patients.
Results: Among 1,191 patients with MGC, 42 patients (3.5%) had LN metastasis. Univariate analysis indicated that age ≤ 50 years (P = 0.045), tumor invasion to the muscularis mucosa (P < 0.001), tumor size > 2 cm (P = 0.014), presence of ulceration (P = 0.01), diffuse type as per Lauren classification (P = 0.005), and undifferentiated-type histology (P = 0.001) were associated with LN metastasis. Moreover, multivariate analysis indicated that tumor invasion to the muscularis mucosa (P = 0.001; odds ratio [OR], 4.909), presence of ulceration (P = 0.036; OR, 1.982), and undifferentiated-type histology (P = 0.025; OR, 4.233) were independent risk factors for LN metastasis. In particular, LN metastasis was observed in some MGC cases with indications for ESD, including absolute indications (1 of 179, 0.6%) and expanded indications (9 of 493, 1.8%).
Conclusion: Although MGC patients can be treated via ESD, we recommend that they undergo a more aggressive treatment strategy if they have tumor invasion to the muscularis mucosa, ulceration, or undifferentiated-type histology in the final pathology report.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Katai H. / 2005 / Early gastric cancer : concepts, diagnosis, and management / Int J Clin Oncol 10 : 375 ~ 383
[학술지(정기간행물)] - 안정식 / 2001 / 조기위암의 재발 / Journal of Gastric Cancer 1 (3) : 180 ~ 186
[학술지(정기간행물)] - Yamao T. / 1996 / Risk factors for lymph node metastasis from intramucosal gastric carcinoma / Cancer 77 : 602 ~ 606
[학술지(정기간행물)] - Lee JH. / 2005 / A prospective ran domized study comparing open vs lapar oscopy-assisted distal gastrectomy in early gastric cancer : early results / Surg Endosc 19 : 168 ~ 173
[학술지(정기간행물)] - Kitano S. / 2002 / A randomized con trolled trial comparing open vs laparos copy-assisted distal gastrectomy for the treatment of early gastric cancer: an interim report / Surgery 131 (1 Suppl) : S306 ~ S311
[학술지(정기간행물)] - 안정식 / 2001 / 조기위암의 재발 / Journal of Gastric Cancer 1 (3) : 180 ~ 186
[학술지(정기간행물)] - Yamao T. / 1996 / Risk factors for lymph node metastasis from intramucosal gastric carcinoma / Cancer 77 : 602 ~ 606
[학술지(정기간행물)] - Lee JH. / 2005 / A prospective ran domized study comparing open vs lapar oscopy-assisted distal gastrectomy in early gastric cancer : early results / Surg Endosc 19 : 168 ~ 173
[학술지(정기간행물)] - Kitano S. / 2002 / A randomized con trolled trial comparing open vs laparos copy-assisted distal gastrectomy for the treatment of early gastric cancer: an interim report / Surgery 131 (1 Suppl) : S306 ~ S311
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UCI(KEPA) : I410-ECN-0101-2017-514-001094346