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Perfluorooctane sulfonate (PFOS) is one of the most widely distributed environmental pollutants and causes neurotoxicities. Fucoidan is a main bioactive constituent of the brown seaweed and has many functions in a variety of physiological conditions. The present study attempted to investigate the potential role of fucoidan as neuroprotective marine polypeptide in environmental pollutant-induced apoptosis of neuronal cells in culture. MTT assay showed that cell viability was significantly reduced to 68 % at 30 μM PFOS, which was recovered up to 77% and 92% in the presence of fucoidan 25 and 50 μg/ml, respectively. Cytotoxicity assay showed that LDH release was significantly increased to 160% at 30 μM PFOS but was reduced to 150% and 122% in the presence of fucoidan 25 and 50 μg/ml, respectively. Caspase-3 activity, a hallmark of apoptosis, was measured to determine the cytotoxicity of PFOS and the cytoprotective effects of fucoidan. PFOS induced a 250% increase of caspase-3 activity at 30 μM but the increase was dampened to 180% and 130% in the presence of fucoidan 25 and 50 μg/ml, respectively. PFOS 30 μM induced 180 % increase in ROS accumulation, which was effectively blocked by 50 μg/ml fucoidan (120% of control). Our results demonstrated that PFOS is a powerful neurotoxicant and fucoidan may be a protective marine bioactive polypeptide against the neurotoxic environmental pollutants.It may contribute to establishing the potential role of fucoidan as a neuroprotective polypeptide that prevents the risk of neurological disorders from the possible neurotoxic pollutants.
목차
Abstract
Introduction
Materials and Method
Results
Discussion
References
참고문헌 (24)
참고문헌 신청
Giesy, J.P. / 2002 / Perfluorochemical surfactants in the environment / Environ. Sci. Technol. 36:146A~152A
Harada, K. H. / 2010 / Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994-2008 and Vietnam in 2007-2008 / Chemosphere 79:314~319
Lau, C. / 2007 / Perfluoroalkyl acids: a review of monitoring and toxicological findings / Toxicol. Sci. 99:366~394
Kannan, K. / 2005 / Perfluorinated compounds in aquatic organisms at various trophic levels in a Great Lakes food chain / Arch. Environ. Contam. Toxicol. 48:559~566
Fox, N. / 2012 / When, where, and how does Alzheimer's disease start? / Lancet Neurol 11:1017~1018
Harada, K. H. / 2010 / Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994-2008 and Vietnam in 2007-2008 / Chemosphere 79:314~319
Lau, C. / 2007 / Perfluoroalkyl acids: a review of monitoring and toxicological findings / Toxicol. Sci. 99:366~394
Kannan, K. / 2005 / Perfluorinated compounds in aquatic organisms at various trophic levels in a Great Lakes food chain / Arch. Environ. Contam. Toxicol. 48:559~566
Fox, N. / 2012 / When, where, and how does Alzheimer's disease start? / Lancet Neurol 11:1017~1018
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UCI(KEPA) : I410-ECN-0101-2018-472-000969469