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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 408 - 419 (12page)
- DOI
- 10.17495/easdl.2017.8.27.4.408
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This study was carried out to compare the relationship between biochemical indices and bone mineral density (BMD) in 50 pre-menopausal and 50 post-menopausal women. The subjects were divided into normal and risk groups according to their bone status, as determined by T-scores of the lumbar spine and femur. The average T-score of the lumbar spine was higher (p<0.05) in pre-menopausal women (0.42±0.18) than post-menopausal women (—0.08±0.21). Serum levels of HDL-cholesterol, P, and Fe were significantly higher in the risk group than the normal group in pre-menopausal women (p<0.05). Serum levels of total protein, globulin, alkaline phosphatase (ALP), and osteocalcin were lower in the risk group than the normal group, whereas the level of estrogen was higher in the normal group than the risk group in post-menopausal women (p<0.05). In pre-menopausal women, P was positively correlated with Ca (p<0.01), and ALP was positively correlated with osteocalcin (p<0.01) and parathyroid hormone (PTH) (p<0.05). Further, insulin-like growth factor-Ⅰ (IGF-I) was negatively correlated with the vitamin 25(OH)D<SUB>3</SUB> and vitamin K (p<0.05). In post- menopausal women, the Ca was positively correlated with vitamin 25(OH)D<SUB>3</SUB> (p<0.05) and vitamin K (p<0.01), and P was positively correlated with vitamin K (p<0.01), Ca (p<0.01), and IGF-I (p<0.05) and negatively correlated with PTH (p<0.05). IGF-I was negatively correlated with PTH (p<0.01) and estrogen (p<0.05), and ALP was positively correlated with osteocalcin (p<0.01) and negatively correlated with vitamin K and estrogen (p<0.05). In pre-menopausal women, the lumbar spine BMD was positively correlated with vitamin K level (p<0.01) and negatively correlated with P level (p<0.05). In post-menopausal women, the femur BMD was positively correlated with estrogen level and negatively correlated with PTH leves (p<0.05). These results suggest that vitamin K and P levels are associated with bone health in pre-menopausal women, and estrogen and PTH levels are associated with bone health in post-menopausal women.
목차
ABSTRACT
서론
연구 방법
결과 및 고찰
요약 및 결론
REFERENCES
참고문헌 (70)
참고문헌 신청
[학술지(정기간행물)] - Angus R / 1988 / Dietary intake and bone mineral density / Bone Miner 4 (3) : 265 ~ 277
[학술지(정기간행물)] - Bai XC / 2004 / Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappa B / Biochem Biophys Res Commun 314 (1) : 197 ~ 207
[학술지(정기간행물)] - Barrett-Connor E / 1998 / Gender differen- ces in insulin-like growth factor and bone mineral density association in old age: The rancho Bernardo study / Journal of Bone and Mineral Research 13 (8) : 1343 ~ 1349
[학술지(정기간행물)] - Bikle D / 2001 / The skeletal structure of insulin-like growth factor Ⅰdeficient mice / J Bone Miner Res 16 (12) : 2320 ~ 2329
[학술지(정기간행물)] - Bischoff-Ferrari HA / 2012 / Vitamin D and fracture preven- tion / Rheum Dis Clin North Am 38 (1) : 107 ~ 113
[학술지(정기간행물)] - Bai XC / 2004 / Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappa B / Biochem Biophys Res Commun 314 (1) : 197 ~ 207
[학술지(정기간행물)] - Barrett-Connor E / 1998 / Gender differen- ces in insulin-like growth factor and bone mineral density association in old age: The rancho Bernardo study / Journal of Bone and Mineral Research 13 (8) : 1343 ~ 1349
[학술지(정기간행물)] - Bikle D / 2001 / The skeletal structure of insulin-like growth factor Ⅰdeficient mice / J Bone Miner Res 16 (12) : 2320 ~ 2329
[학술지(정기간행물)] - Bischoff-Ferrari HA / 2012 / Vitamin D and fracture preven- tion / Rheum Dis Clin North Am 38 (1) : 107 ~ 113
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UCI(KEPA) : I410-ECN-0101-2018-594-001271194