지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 388 - 395 (8page)
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초록· 키워드
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BACKGROUND/OBJECTIVES: Although Korean fermented foods contain large amounts of salt, which is known to exacerbate health problems, these foods still have beneficial effects such as anti-hypertension, anti-cancer, and anti-colitis properties. We hypothesized that ganjang may have different effects on blood pressure compared to same concentrations of salt.
MATERIALS/METHODS: Sprague-Dawley rats were divided into control (CT), NaCl (NC), and ganjang (GJ) groups and orally administered with 8% NaCl concentration for 9 weeks. The systolic blood pressure (SBP), serum chemistry, Na<SUP>+</SUP> and K<SUP>+</SUP> concentrations and renal gene expressions were measured.
RESULTS: The SBP was significantly increased in the NC group compared to the GJ and CT groups. In addition, the Na<SUP>+</SUP> concentration in urine was higher in the GJ and NC groups than the CT group, but the urine volume was increased in the GJ group compared to the other groups. The serum renin levels were decreased in the GJ group compared to the CT group, while the serum aldosterone level was decreased in the GJ group relative to the NC group. The mRNA expression of the renin, angiotensin II type I receptor, and mineralocorticoid receptor were significantly lower in the GJ group compared to other groups. Furthermore, GJ group showed the lowest levels of genes for Na+ transporter in kidney cortex such as Na<SUP>+</SUP>/K<SUP>+</SUP> ATPaseα1 (NKAα1), Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger 3 (NHE3), Na+/HCO₃- co-exchanger (NBC), and carbonic anhydrases II (CAII).
CONCLUSIONS: The decreased SBP in the GJ could be due to decreased renin and aldosterone levels in serum and increased urinary volume and excretion of Na<SUP>+</SUP> with its transporter gene alteration. Therefore, ganjang may have antihypertensive effect despite its high contents of salt.
MATERIALS/METHODS: Sprague-Dawley rats were divided into control (CT), NaCl (NC), and ganjang (GJ) groups and orally administered with 8% NaCl concentration for 9 weeks. The systolic blood pressure (SBP), serum chemistry, Na<SUP>+</SUP> and K<SUP>+</SUP> concentrations and renal gene expressions were measured.
RESULTS: The SBP was significantly increased in the NC group compared to the GJ and CT groups. In addition, the Na<SUP>+</SUP> concentration in urine was higher in the GJ and NC groups than the CT group, but the urine volume was increased in the GJ group compared to the other groups. The serum renin levels were decreased in the GJ group compared to the CT group, while the serum aldosterone level was decreased in the GJ group relative to the NC group. The mRNA expression of the renin, angiotensin II type I receptor, and mineralocorticoid receptor were significantly lower in the GJ group compared to other groups. Furthermore, GJ group showed the lowest levels of genes for Na+ transporter in kidney cortex such as Na<SUP>+</SUP>/K<SUP>+</SUP> ATPaseα1 (NKAα1), Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger 3 (NHE3), Na+/HCO₃- co-exchanger (NBC), and carbonic anhydrases II (CAII).
CONCLUSIONS: The decreased SBP in the GJ could be due to decreased renin and aldosterone levels in serum and increased urinary volume and excretion of Na<SUP>+</SUP> with its transporter gene alteration. Therefore, ganjang may have antihypertensive effect despite its high contents of salt.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCE
참고문헌 (37)
참고문헌 신청
Poulter NR, Prabhakaran D, Caulfield M. Hypertension. Lancet 2015;386:801-12.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003;42:1206-52.
Schunkert H, Ingelfinger JR, Hirsch AT, Pinto Y, Remme WJ, Jacob H, Dzau VJ. Feedback regulation of angiotensin converting enzyme activity and mRNA levels by angiotensin II. Circ Res 1993;72:312-8.
Trepiccione F, Zacchia M, Capasso G. The role of the kidney in salt-sensitive hypertension. Clin Exp Nephrol 2012;16:68-72.
de Wardener HE, He FJ, MacGregor GA. Plasma sodium and hypertension. Kidney Int 2004;66:2454-66.
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UCI(KEPA) : I410-ECN-0101-2018-594-001333539