지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 339 - 347 (9page)
이용수
초록· 키워드
오류제보하기
This study was performed to evaluate the cytotoxicity induced by ischemia-like condition (ILC) in cultured neuroglial cells (C6 glioma cells). The protective effect of kaempferol (KAE), flavonoid against the cytotoxicity induced by ILC induction was assessed. In addition, antioxidative effects of KAE were done by colorimetric assays. Cell viability and the antioxidative effects such as DPPH-radical scavenging activity, superoxide dismutase (SOD)-like activity and inhibitory activity of lipid peroxidation (LP) were analyzed. ILC induction decreased cell viability in a dose-dependent manner, and the XTT<SUB>90</SUB> value (low cytotoxicity value) and XTT<SUB>50</SUB> value (high cytotoxicity value) were determined during ILC induction for 15 and 40 minutes, respectively. The butylated hydroxytoluene (BHT) antioxidant significantly increased cell viability damaged by the ILC-induced cytotoxicity. In the protective effect of KAE on ILC-induced cytotoxicity, KAE protected the ILC-induced cytotoxicity by the significant increase of cell viability, and also it showed DPPH-radical scavenging ability, SOD-like ability and inhibitory ability of LP. From these results, it is suggested that ILC induction showed cytotoxicity in these cultures and the oxidative stress is involved in the ILC-induced cytotoxicity. While, KAE prevented ILC-induced cytotoxicity by antioxidative effects. In conclusion, natural products like KAE may be a putative therapeutic agent for the treatment of disease associated with oxidative stress such as ischemia.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (29)
참고문헌 신청
Blois MS. Antioxidant determination by the use of a stable free radical. Nature. 1958. 26: 1199-1200.
EI-Sayed NH, Omara NM, Yousef AK, Farag AM, Mabry TJ. Kaempferol triosides from Reseda muricata. Phytochem. 2001. 57: 575-578.
Endoh M, Maiese K, Wanger J. Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia. Brain Research. 1994. 651: 92-100.
Gates MA, Tworoger SS, Hecht JL, De Vivo I, Rosner B, Hankinson SE. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. International Journal of Cancer. 2007. 121: 2225-2232.
Gracia-Lopez D, Cuevas MJ, Almar M, Lima E, De Paz JA, Gonzalez-Gallego J. Effects of eccentric exercise on NF-κB activation in blood mononuclear cells. Medicine & Science in Sports & Exercise. 2007. 39: 653-664.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Innate Lymphoid Cells and Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2017 .06
-
Comparison of Clinicopathological Features and Treatment Results between Invasive Lobular Carcinoma and Ductal Carcinoma of the Breast
Journal of Breast Cancer
2015 .01
-
The Antioxidative Effect of Eclipta prostrata L. Extract on Cultured NIH3T3 Fibroblasts Injured by Manganese-Induced Cytotoxicity
대한의생명과학회지
2018 .12
-
Protective Effect of Aster tataricus L. Extract on the Dermal Cytotoxicity Induced by Sodium Bromate, Oxidant of Hair Dye
대한의생명과학회지
2019 .12
-
Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease
Immune Network
2025 .02
-
금속매염제인 초산구리의 세포독성에 대한 자귀나무잎 추출물의 보호 효과
한국환경보건학회지
2019 .01
-
The role of innate lymphoid cells in the airway inflammations
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Innate Lymphoid Cells in COVID-19: Bystanders or Active Contributors?
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2024 .12
-
Innate Lymphoid Cells in the Airways: Their Functions and Regulators
Allergy, Asthma & Immunology Research
2020 .01
-
황산카드뮴독성의 산화적 손상에 대한 부들 추출물의 항산화 효과
한국환경보건학회지
2019 .01
-
Expression of Sarcosine Metabolism-Related Proteins in Invasive Lobular Carcinoma: Comparison to Invasive Ductal Carcinoma
Yonsei Medical Journal
2015 .01
-
환경오염원인 납의 신경독성에 대한 NMDA 수용체 길항제의 보호 효과
한국산업보건학회지
2017 .01
-
Type 2 Innate Lymphoid Cells and Skin Fibrosis in a Murine Model of Atopic Dermatitis-Like Skin Inflammation
Journal of Korean Medical Science
2024 .08
-
Innate Type 2 Response to Aspergillus fumigatus in a Murine Model of Atopic Dermatitis?like Skin Inflammation
Journal of Korean Medical Science
2021 .10
-
BIAN N-Heterocyclic Gold Carbene Complexes induced cytotoxicity in human cancer cells via upregulating oxidative stress
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2021 .01
-
Cytotoxicity of PM2.5 components from anthropogenic sources
환경독성보건학회 심포지엄 및 학술대회
2016 .06
-
Investigation of the cytotoxicity of thermoplastic denture base resins
The Journal of Advanced of Prosthodontics
2017 .01
-
Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis
Immune Network
2018 .02
-
Inhibition cell growth and cytotoxicity in lung epithelial cell assessment of BIT and EG mixtures
환경독성보건학회 심포지엄 및 학술대회
2015 .06
이 논문의 저자 정보
이 논문과 함께 이용한 논문
IoT환경에 대한 블록체인과 탱글의 비교분석
우상호
,
이상길
,
신재권
외 2명
한국통신학회 학술대회논문집
2019
.01
“초지능 시대와 미래” 특집을 내면서
임광혁
한국콘텐츠학회지
2019
.03
초연결(IoT) 초지능(AI) 시대에 요구되는 인재는?
김현수
한국자동차공학회 Workshop
2018
.08
API-call Constraint Checking Considering Alarms and ISRs for IoT Device Control Software
김동우
,
최윤자
Journal of KIISE
2018
.12
Protective effect of Cirsium japonicum var. maackii against oxidative stress in C6 glial cells
Ah Young Lee
,
Min Jeong Kim
,
Sanghyun Lee
외 2명
Korean Journal of Agricultural Science
2018
.09
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-510-001723237