Ginsenoside Rg3 promotes inflammation resolution through M2 macrophage polarization

Saeromi Kang; Soo-Jin Park; Ae-Yeon Lee; Jin Huang; Hae-Young Chung; Dong-Soon Im

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자료유형: 학술저널

저자정보: Saeromi Kang (Pusan National University) Soo-Jin Park (Pusan National University) Ae-Yeon Lee (Pusan National University) Jin Huang (Pusan National University) Hae-Young Chung (Pusan National University) Dong-Soon Im (Pusan National University)

저널정보: 고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.42 No.1

발행연도: 2018.1

수록면: 68 - 74 (7page)

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Background: Ginsenosides have been reported to have many health benefits, including antiinflammatory effects, and the resolution of inflammation is now considered to be an active process driven by M2-type macrophages. In order to determine whether ginsenosides modulate macrophage phenotypes to reduce inflammation, 11 ginsenosides were studied with respect to macrophage polarization and the resolution of inflammation.
Methods: Mouse peritoneal macrophages were polarized into M1 or M2 phenotypes. Reverse transcription-polymerase chain reaction, Western blotting, and measurement of nitric oxide (NO) and prostaglandin E2 levels were performed in vitro and in a zymosan-induced peritonitis C57BL/6 mouse model.
Results: Ginsenoside Rg₃ was identified as a proresolving ginseng compound based on the induction of M2 macrophage polarization. Ginsenoside Rg₃ not only induced the expression of arginase-1 (a representative M2 marker gene), but also suppressed M1 marker genes, such as inducible NO synthase, and NO levels. The proresolving activity of ginsenoside Rg₃ was also observed in vivo in a zymosan-induced peritonitis model. Ginsenoside Rg₃ accelerated the resolution process when administered at peak inflammatory response into the peritoneal cavity.
Conclusion: These results suggest that ginsenoside Rg₃ induces the M2 polarization of macrophages and accelerates the resolution of inflammation. This finding opens a new avenue in ginseng pharmacology.

#ginseng #ginsenoside Rg3 #inflammation #resolution

참고문헌 (23)

참고문헌 신청

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[학술지(정기간행물)] - Shin YM / 2013 / Antioxidative, anti-inflammatory, and matrix metalloproteinase inhibitory activities of 20(S)-ginsenoside $Rg_3$ in cultured mammalian cell lines / Mol Biol Rep 40 : 269 ~ 279

[학술지(정기간행물)] - Jovanovski E / 2014 / Effect of $Rg_3$-enriched Korean red ginseng (Panax ginseng) on arterial stiffness and blood pressure in healthy individuals: a randomized controlled trial / J Am Soc Hypertens 8 : 537 ~ 541

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