지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 54 - 63 (10page)
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Objectives：QTc prolongation is associated with fatal arrhythmias, particularly torsades de pointes and sudden cardiac death. However, little is known regarding the risk factors for QTc prolongation in in-patients with chronic schizophrenia who take antipsychotics. This study aimed to explore the association between QTc and demographic variables, metabolic parameters and prescribed medications in-patients with chronic schizophrenia who take antipsychotics.
Methods：We examined 200 in-patients with chronic schizophrenia who were taking antipsychotics in a long-term psychiatric hospital. Demographic and clinical variables, including ECG and prescribed medications, were retrospectively obtained from medical charts. QTc prolongation was defined as increased QTc intervals greater than 450ms in men and 470ms in women. The associations between QTc and other continuous variables were assessed using correlation and regression analyses, and a secondary analysis of interaction effects was performed among significant variables.
Results：The prevalence of QTc prolongation inpatients with schizophrenia was 33.1%. After controlling for significant variables, linear regression analysis revealed that QT interval was influenced by a total antipsychotic dose(β=0.19, p<0.01). There was a significant interaction effect between total antipsychotics dose and cigarette smoking with QTc as the dependent variable(β=-0.36, p<0.01).
Conclusion：The total antipsychotics dose is associated with QTc prolongation in a dose-related manner. It is important for psychiatrists to consider various factors when prescribing antipsychotics and to regularly check patients’ ECG.
Methods：We examined 200 in-patients with chronic schizophrenia who were taking antipsychotics in a long-term psychiatric hospital. Demographic and clinical variables, including ECG and prescribed medications, were retrospectively obtained from medical charts. QTc prolongation was defined as increased QTc intervals greater than 450ms in men and 470ms in women. The associations between QTc and other continuous variables were assessed using correlation and regression analyses, and a secondary analysis of interaction effects was performed among significant variables.
Results：The prevalence of QTc prolongation inpatients with schizophrenia was 33.1%. After controlling for significant variables, linear regression analysis revealed that QT interval was influenced by a total antipsychotic dose(β=0.19, p<0.01). There was a significant interaction effect between total antipsychotics dose and cigarette smoking with QTc as the dependent variable(β=-0.36, p<0.01).
Conclusion：The total antipsychotics dose is associated with QTc prolongation in a dose-related manner. It is important for psychiatrists to consider various factors when prescribing antipsychotics and to regularly check patients’ ECG.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (40)
참고문헌 신청
[학술지(정기간행물)] - Koponen H / 2008 / Schizophrenia and sudden cardiac death / Nordic J Psychiatry 62 : 342 ~ 345
[학술지(정기간행물)] - Faber TS / 1994 / Drug-induced torsade de pointes / Drug Safety 11 : 463 ~ 466
[학술지(정기간행물)] - Algra A / 1991 / QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest / Circulation 83 (6) : 1888 ~ 1894
[학술지(정기간행물)] - Fayssoil A / 2011 / Torsade de pointes induced by citalopram and amiodarone / Annales de Cardiologie et D'angeiologie 60 : 165 ~ 168
[학술지(정기간행물)] - Moss AJ / 1993 / Measurement of the QT interval and the risk associated with QTc interval prolongation: a review / Am J Cardiol 72 : 23 ~ 25
[학술지(정기간행물)] - Faber TS / 1994 / Drug-induced torsade de pointes / Drug Safety 11 : 463 ~ 466
[학술지(정기간행물)] - Algra A / 1991 / QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest / Circulation 83 (6) : 1888 ~ 1894
[학술지(정기간행물)] - Fayssoil A / 2011 / Torsade de pointes induced by citalopram and amiodarone / Annales de Cardiologie et D'angeiologie 60 : 165 ~ 168
[학술지(정기간행물)] - Moss AJ / 1993 / Measurement of the QT interval and the risk associated with QTc interval prolongation: a review / Am J Cardiol 72 : 23 ~ 25
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