지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.24 No.2
- 발행연도
- 2019.6
- 수록면
- 165 - 170 (6page)
- DOI
- 10.3746/pnf.2019.24.2.165
이용수
초록· 키워드
오류제보하기
This study was performed to investigate the effect of aged black garlic ethyl acetate extract on scopolamineinduced cognitive impairment in mice. Aged garlic ethyl acetate extract (BG) was administrated at a dose of 25 or 50 ㎎/㎏ in scopolamine-induced mice. Cognitive ability was evaluated using a Morris water maze test and a passive avoidance test. BGs (50 ㎎/㎏) shortened the latency time that was increased by scopolamine and increased the platform crossing numbers that was significantly shortened by scopolamine after 5 days training in the Morris water maze test (P＜0.05). BG (50 ㎎/㎏) also significantly prolonged the latency time in the passive avoidance test (P＜0.05). Result from biochemical analysis showed that BG increased levels of glutathione, glutathione peroxidase activity, and glutathione reductase activity, whereas BG significantly inhibited lipid peroxidation (P＜0.05). BG also attenuated cholinergic degradation through inhibiting acetylcholinesterase activity and increasing choline acetyltransferase activity (P＜0.05). In conclusion, BG protected against scopolamine-induced cognitive impairment through decreasing oxidative damage and regulating cholinergic function in the brains of mice. BG may therefore be a beneficial food for protecting against neurodegeneration such as Alzheimer’s disease.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
Ahmad MS / 2006 / Antiglycation properties of aged garlic extract : possible role in prevention of diabetic complications / J Nutr 136:796S~799S
Araujo JA / 2005 / Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging / Prog Neuropsychopharmacol Biol Psychiatry 29:411~422
Budzynska B / 2015 / Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice / Psychopharmacology 232:931~942
Butt MS / 2009 / Garlic : nature’s protection against physiological threats / Crit Rev Food Sci Nutr 49:538~551
Chauhan NB / 2006 / Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer’s transgenic model Tg2576 / J Ethnopharmacol 108:385~394
Araujo JA / 2005 / Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging / Prog Neuropsychopharmacol Biol Psychiatry 29:411~422
Budzynska B / 2015 / Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice / Psychopharmacology 232:931~942
Butt MS / 2009 / Garlic : nature’s protection against physiological threats / Crit Rev Food Sci Nutr 49:538~551
Chauhan NB / 2006 / Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer’s transgenic model Tg2576 / J Ethnopharmacol 108:385~394
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UCI(KEPA) : I410-ECN-0101-2019-594-000871056