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Objectives: The aim of this study was to investigate the anti-inflammatory effects of Curcuma longa rhizoma extract in an experimental rat model of osteoarthritis.
Methods: Osteoarthritis was induced in rats by injecting monosodium iodoacetate (MIA) into the knee joint cavity of rats. The rats were divided into 5 groups (Normal, Control, positive comparison, low (CL) and high (CH) concentration groups). Rats in the low concentration (CL) group had MIA-induced osteoarthritis; they were treated with Curcuma longa rhizoma extract at a dose of 50㎎/㎏ body weight. Rats in the high concentration (CH) group had MIA-induced osteoarthritis; they were treated with Curcuma longa rhizoma extract at a dose of 100㎎/㎏ body weight. Hind paw weight distribution and ROS levels were measured. At the end of all treatments, changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine levels were analyzed. In addition, inflammatory protein levels were evaluated by western blot analysis.
Results: In this study, hind paw weight distribution significantly improved in the CL and CH groups, while. Reactive oxygen species (ROS) production significantly decreased in both. The levels of ALT, AST, BUN, and creatinine did not significantly change in either group. The production of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), p47<SUP>phox</SUP>, and Ras-related C3 botulinum toxin substrate 1 (RAC1) decreased in both. Catalase, heme oxygenase-1 (HO-1) and superoxide dismutase (SOD) significantly increased in the CL and CH groups, respectively. Nuclear factor erythroid 2 (Nrf2) increased, but there were no significant differences between the experimental and control groups. Inflammatory cytokines, including nuclear factor-kappa Bp65 (NF-κBp65), interleukin-1beta (IL-1β), and tumor necrosis factor-alpha (TNF-α), decreased significantly in both the CL and CH groups.
Conclusions: Our results showed that Curcuma longa rhizoma extract has anti-inflammatory effects. Anti-inflammatory activity is regulated by the inhibition of inflammatory cytokines and mediators, such as NF-κB, therefore, it suppresses cartilage damage as well.
Methods: Osteoarthritis was induced in rats by injecting monosodium iodoacetate (MIA) into the knee joint cavity of rats. The rats were divided into 5 groups (Normal, Control, positive comparison, low (CL) and high (CH) concentration groups). Rats in the low concentration (CL) group had MIA-induced osteoarthritis; they were treated with Curcuma longa rhizoma extract at a dose of 50㎎/㎏ body weight. Rats in the high concentration (CH) group had MIA-induced osteoarthritis; they were treated with Curcuma longa rhizoma extract at a dose of 100㎎/㎏ body weight. Hind paw weight distribution and ROS levels were measured. At the end of all treatments, changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine levels were analyzed. In addition, inflammatory protein levels were evaluated by western blot analysis.
Results: In this study, hind paw weight distribution significantly improved in the CL and CH groups, while. Reactive oxygen species (ROS) production significantly decreased in both. The levels of ALT, AST, BUN, and creatinine did not significantly change in either group. The production of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), p47<SUP>phox</SUP>, and Ras-related C3 botulinum toxin substrate 1 (RAC1) decreased in both. Catalase, heme oxygenase-1 (HO-1) and superoxide dismutase (SOD) significantly increased in the CL and CH groups, respectively. Nuclear factor erythroid 2 (Nrf2) increased, but there were no significant differences between the experimental and control groups. Inflammatory cytokines, including nuclear factor-kappa Bp65 (NF-κBp65), interleukin-1beta (IL-1β), and tumor necrosis factor-alpha (TNF-α), decreased significantly in both the CL and CH groups.
Conclusions: Our results showed that Curcuma longa rhizoma extract has anti-inflammatory effects. Anti-inflammatory activity is regulated by the inhibition of inflammatory cytokines and mediators, such as NF-κB, therefore, it suppresses cartilage damage as well.
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재료 및 방법
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참고문헌
참고문헌 (66)
참고문헌 신청
The Society of Korean Medicine Rehabilitation / 2015 / Korean Rehabilitation Medicine / Koonja publisher :102~151
Korean Acupuncture & Moxibustion Medicine Society / 2016 / Acupuncture Medicine / Hanmibook :537~568
Harrison's Principles of Internal Medicine Edit committee of the Korean Association of Internal Medicine / 2013 / Harrison's Principles of Internal Medicine / MIP :2782
Herbal medicine editorial committee of Korean medicine college / 2011 / Herbal medicine / Younglimsa :454~455
정태산 / 2014 / 강황추출물이 Diethylnitrosamine과 CCl4로 유발된 흰쥐의 간암과 간 손상에 미치는 영향 / 대한한의학 방제학회지 22(1):177~192
Korean Acupuncture & Moxibustion Medicine Society / 2016 / Acupuncture Medicine / Hanmibook :537~568
Harrison's Principles of Internal Medicine Edit committee of the Korean Association of Internal Medicine / 2013 / Harrison's Principles of Internal Medicine / MIP :2782
Herbal medicine editorial committee of Korean medicine college / 2011 / Herbal medicine / Younglimsa :454~455
정태산 / 2014 / 강황추출물이 Diethylnitrosamine과 CCl4로 유발된 흰쥐의 간암과 간 손상에 미치는 영향 / 대한한의학 방제학회지 22(1):177~192
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UCI(KEPA) : I410-ECN-0101-2019-519-000981263