Magnetic Resonance Elastography and Diffusion Weighted Imaging in the Evaluation of Hepatic Fibrosis in Chronic Hepatitis B

Tiffany P. Hennedige; Gang Wang; Fiona P. Leung; Hind S. Alsaif; Lynette LS Teo; 임승지; Aileen Wee; Sudhakar K. Venkatesh

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자료유형: 학술저널

저자정보: Tiffany P. Hennedige Gang Wang Fiona P. Leung Hind S. Alsaif Lynette LS Teo 임승지 Aileen Wee Sudhakar K. Venkatesh

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제11권 제3호

발행연도: 2017.1

수록면: 401 - 408 (8page)

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Background/Aims: Comparison of the accuracy of magnetic resonance elastography (MRE) and diffusion weighted imaging (DWI) for the diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB). Methods: In this retrospective analysis, we investigated 63 patients with CHB and liver fibrosis. DWI was performed with both breath-hold (DWIBH) and free-breathing (DWI-FB) sequences (b=0, 500). The mean liver stiffness and apparent diffusion coefficient (ADC) were calculated by drawing regions of interest maps. Fibrosis staging according to the METAVIR system was independently performed by an experienced pathologist. A receiver operating curve (ROC) analysis was conducted to determine the accuracy of MRE, DWI-BH and DWI-FB in the detection and stratification of liver fibrosis. The performance of the detection of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4) was also evaluated by comparing areas under the ROC. Results: There was a moderate and significantly negative correlation between the ADC values and liver stiffness. The accuracies for the detection of ≥F2/≥F3/F4 stage fibrosis with DWI-FB, DWI-BH and MRE were 0.84/0.76/0.72, 0.72/0.83/0.79 and 0.99/0.99/0.98, respectively. The performance of MRE was significantly better than DWI-FB and DWI-BH. There were no significant differences between the performance of DWI-FB and DWI-BH. Conclusions: MRE is more accurate than DWI for the detection and stratification of liver fibrosis in CHB.

#Elastography #Liver cirrhosis #Diffusion weighted imaging #Accuracy #Cirrhosis

참고문헌 (22)

참고문헌 신청

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