지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 262 - 265 (4page)
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초록· 키워드
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Reactivation of hepatitis B virus (HBV) replication is a frequent phenomenon in patients receiving immunosuppressants or chemotherapy. It was recently reported that regional therapy, such as transarterial chemotherapy (TAC) or radiotherapy, can also induce HBV reactivation in patients with hepatocellular carcinoma (HCC), and this can be prevented by preemptive lamivudine treatment. We report an unusual case of fatal hepatitis caused by reactivation of the tyrosine-methionine-aspartate-aspartate (YMDD) lamivudine-resistant strain in a 51-year-old male patient with HCC who was receiving preemptive lamivudine therapy. This patient received combined helical tomotherapy and TAC for the treatment of HCC with pulmonary metastasis. HBV reactivation and hepatitis exacerbation occurred after 2 months of therapy, but preemptive antiviral therapy was continued. Laboratory tests showed that the serum HBV DNA level had increased by more than 10,000-fold and a severe elevation of the aminotransferase level to 1,060 U/L.
Although adefovir was added to lamivudine immediately after detecting the YMDD mutants, the patient eventually died of hepatic failure. Our experience suggests that for preemptive therapy, the use of potent antiviral drugs with a low risk of drug resistance as well as close viral monitoring are important for chronic HBV carriers undergoing intensive anticancer therapy.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Atkins M / 1998 / Lamivudine resistance in chronic hepatitis B / J Hepatol 28 : 169 ~
Chou CH / 2007 / Radiation-induced hepatitis B virus reactivation in liver mediated by the bystander effect from irradiated endothelial cells / Clin Cancer Res 13 : 851 ~ 85
Hong TS / 2007 / Megavoltage computed tomography: an emerging tool for image-guided radiotherapy / Am J Clin Oncol 30 : 617 ~ 623
Honkoop P / 1997 / Lamivudine resistance in immunocompetent chronic hepatitis B. Incidence and patterns / J Hepatol 26 : 1393 ~ 1395
Jang JW / 2004 / Transarterial chemo-lipiodolization can reactivate hepatitis B virus replication in patients with hepatocellular carcinoma / J Hepatol 41 : 427 ~ 435
Chou CH / 2007 / Radiation-induced hepatitis B virus reactivation in liver mediated by the bystander effect from irradiated endothelial cells / Clin Cancer Res 13 : 851 ~ 85
Hong TS / 2007 / Megavoltage computed tomography: an emerging tool for image-guided radiotherapy / Am J Clin Oncol 30 : 617 ~ 623
Honkoop P / 1997 / Lamivudine resistance in immunocompetent chronic hepatitis B. Incidence and patterns / J Hepatol 26 : 1393 ~ 1395
Jang JW / 2004 / Transarterial chemo-lipiodolization can reactivate hepatitis B virus replication in patients with hepatocellular carcinoma / J Hepatol 41 : 427 ~ 435
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