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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 117 - 125 (9page)
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초록· 키워드
오류제보하기
Most of the cancers are still incurable human diseases.
According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. Most of all, the presence of CSCs is closely associated with tumorigenesis and therapeutic resistance. Despite the numerous efforts to target CSCs, current anti-cancer therapies are still impeded by CSC-derived cancer malignancies; increased metastases, tumor recurrence, and even acquired resistance against the anti-CSC therapies developed in experimental models. One of the most forceful underlying reasons is a “cancer heterogeneity” due to “CSC plasticity”. A comprehensive understanding of CSC-derived heterogeneity will provide novel insights into the establishment of efficient targeting strategies to eliminate CSCs. Here, we introduce findings on mechanisms of CSC reprogramming and CSC plasticity, which give rise to phenotypically varied CSCs. Also, we suggest concepts to improve CSC-targeted therapy in order to overcome therapeutic resistance caused by CSC plasticity and heterogeneity.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
[학술지
Al-Hajj M / 2003 / Prospective identification of tumorigenic breast cancer cells / Proc Natl Acad Sci U S A 100 : 3983 ~ 3988
Bao S / 2006 / Glioma stem cells promote radioresistance by preferential activation of the DNA damage response / Nature 444 : 756 ~ 760
Bonnet D / 1997 / Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell / Nat Med 3 : 730 ~ 737
Brooks MD / 2015 / Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer / Cell Stem Cell 17 : 260 ~ 271
Al-Hajj M / 2003 / Prospective identification of tumorigenic breast cancer cells / Proc Natl Acad Sci U S A 100 : 3983 ~ 3988
Bao S / 2006 / Glioma stem cells promote radioresistance by preferential activation of the DNA damage response / Nature 444 : 756 ~ 760
Bonnet D / 1997 / Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell / Nat Med 3 : 730 ~ 737
Brooks MD / 2015 / Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer / Cell Stem Cell 17 : 260 ~ 271
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