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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 127 - 133 (7page)
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초록· 키워드
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H2O2, a member of reactive oxygen species (ROS), is known to be involved in the mediation of physiological functions in a variety of cell types. However, little has been known about the physiological role of H2O2 in exocrine cells. Therefore, in the present study, the effect of H2O2 on cholecystokinin (CCK)-evoked Ca2+ mobilization and amy-lase release was investigated in rat pancreatic acinar cells. Stimulation of the acinar cells with sulfated octapeptide form of CCK (CCK-8S) induced biphasic increase in amylase release. Addition of 30 M H2O2 enhanced amylase release caused by 10 pM CCK-8S, but inhibited the amylase release induced by CCK-8S at concentrations higher than 100 pM. An ROS scavenger, 10 M Mn(III)tetrakis(4-benzoic acid)porphyrin chloride, increased amylase release caused by CCK-8S at concentrations higher than 100 pM, although lower concentrations of CCK-8S-induced amylase release was not affected. To examine whether the effect of H2O2 on CCK-8S-induced amylase release was exerted via modu-lation of intracellular Ca2+ signaling, we measured the changes in intracellular Ca2+ concentration ([Ca2+]i) in fura-2 loaded acinar cells. Although 30 M H2O2 did not induce any increase in [Ca2+]i by itself, it increased the frequency and amplitude of [Ca2+]i oscillations caused by 10 pM CCK-8S. However, 30 M H2O2 had little effect on 1 nM CCK-8S-induced increase in [Ca2+]i. ROS scavenger, 1 mM N-acetylcysteine, did not affect [Ca2+]i changes induced by 10 pM or 1 nM CCK-8S. Therefore, it was concluded that 30 M H2O2 enhanced low concentration of CCK-8S-induced amylase release probably by increasing [Ca2+]i oscillations while it inhibited high concentration of CCK-8S-induced amylase release.
목차
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참고문헌 (27)
참고문헌 신청
/ 1985 / A new generation of Ca2+ indicators with greatly improved fluorescence properties : 3440 ~ 3450
/ 1989 / CCK-JMV-180: a peptide that distingui-shes high-affinity cholecystokinin receptors from low-affinity cholecystokinin receptors. Biochim 1010 : 145 ~ 150
/ 1990 / Two functionally distinct cholecystokinin receptors show different modes of actions on Ca2+ mobilization and phospholipid hydrolysis in isolated rat pancreatic acin
/ 1993 / The pattern of agonist-evoked cytosolic Ca2+ oscillations depends on the resting intracellular Ca2+ concentration : 18654 ~ 18658
/ 1994 / Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells : 1079 ~ 1088
/ 1989 / CCK-JMV-180: a peptide that distingui-shes high-affinity cholecystokinin receptors from low-affinity cholecystokinin receptors. Biochim 1010 : 145 ~ 150
/ 1990 / Two functionally distinct cholecystokinin receptors show different modes of actions on Ca2+ mobilization and phospholipid hydrolysis in isolated rat pancreatic acin
/ 1993 / The pattern of agonist-evoked cytosolic Ca2+ oscillations depends on the resting intracellular Ca2+ concentration : 18654 ~ 18658
/ 1994 / Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells : 1079 ~ 1088
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