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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 133 - 140 (8page)
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초록· 키워드
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Resveratrol (3,4',5,-trihydroxystilbene), a phytoalexin present in grapes, exerts a variety of actions to reduce superoxides, prevents diabetes mellitus, and inhibits inflammation. Resveratrol acts as a chemo-preventive agent and induces apoptotic cell death in various cancer cells. However, the role of resveratrol in odontoblastic cell differentiation is unclear. In this study, the effect of resveratrol on regulating odontoblast differentiation was examined in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. Resveratrol significantly accelerated mineralization as compared with the control culture in differentiation of MDPC-23 cells. Resveratrol significantly increased expression of ALP mRNA as compared with the control in differentiation of MDPC-23 cells. Resveratrol significantly accelerated expression of Col ⅠmRNA as compared with the control in differentiation of MDPC-23 cells. Resveratrol significantly increased expressions of DSPP and DMP-1 mRNAs as compared with the control in differentiation of MDPC-23 cells. Treatment of resveratrol did not significantly affect cell proliferation in MDPC-23 cells. Results suggest resveratrol facilitates odontoblast differentiation and mineralization in differentiation of MDPC-23 cells, and may have potential properties for development and clinical application of dentin regeneration materials.
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참고문헌 (33)
참고문헌 신청
Lee DS / 2011 / Crosstalk between nuclear factor I-C and transforming growth factor-${\beta}$ 1 signaling regulates odontoblast differentiation and homeostasis / PLoS One 6:e29160
Mina M1 / 1987 / The induction of odontogenesis in non-dental mesenchyme combined with early murine mandibular arch epithelium / Arch Oral Biol 32:123~127
Ruch JV / 1998 / Odontoblast commitment and differentiation / Biochem Cell Biol 76:923~938
Sun Q / 2013 / MicroRNA-338-3p promotes differentiation of mDPC6T into odontoblast-like cells by targeting Runx2 / Mol Cell Biochem 377:143~149
조지호 / 2015 / MicroRNA-27 Promotes Odontoblast Differentiation via Wnt1 Signaling / International Journal of Oral Biology 40(4):197~204
Mina M1 / 1987 / The induction of odontogenesis in non-dental mesenchyme combined with early murine mandibular arch epithelium / Arch Oral Biol 32:123~127
Ruch JV / 1998 / Odontoblast commitment and differentiation / Biochem Cell Biol 76:923~938
Sun Q / 2013 / MicroRNA-338-3p promotes differentiation of mDPC6T into odontoblast-like cells by targeting Runx2 / Mol Cell Biochem 377:143~149
조지호 / 2015 / MicroRNA-27 Promotes Odontoblast Differentiation via Wnt1 Signaling / International Journal of Oral Biology 40(4):197~204
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