지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제49권 제3호
- 발행연도
- 2015.1
- 수록면
- 243 - 248 (6page)
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초록· 키워드
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Background: Follicular lymphomas present with various immunohistologic patterns. The immunohistochemical markers used in the diagnosis of follicular lymphoma show variable degrees of sensitivity and specificity, and thus, additional germinal center markers are required. Smad1 has been reported to be overexpressed in follicular lymphoma, but little is known regarding the expression patterns of Smad proteins in human lymphoid tissue. Methods: In the present study, we performed immunohistochemistry for traditional germinal center markers and for Smad1 in human reactive lymphoid and follicular lymphoma tissues to investigate Smad1’s usefulness in the diagnosis of follicular lymphoma. Results: In the reactive germinal centers, most cells were positive for Smad1. Among the 27 follicular lymphoma cases, 17 of 21 (80%) were Smad1 positive, 17 of 27 (63%) were positive for CD10, and 23 of 27 (85%) were positive for Bcl6. Notably, three cases expressed CD10 only, and one only expressed Bcl6. All these cases were grade 3 tumors and showed follicular and diffuse growth patterns. Conclusions: These results indicate that Smad1 is a candidate as a germinal center marker. Furthermore, they suggest that the Smad signaling pathway might be involved in follicular lymphoma.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Alizadeh AA / 2000 / Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling / Nature 403 : 503 ~ 511
Borovecki A / 2008 / Prognostic significance of B-cell differentiation genes encoding proteins in diffuse large B-cell lymphoma and follicular lymphoma grade 3 / Croat Med J
Eshoa C / 2001 / Decreased CD10 expression in grade III and in interfollicular infiltrates of follicular lymphomas / Am J Clin Pathol 115 : 862 ~ 867
Flanders KC / 2001 / Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo : signaling by BMPs and TGF-betas / Dev Dyn 220 : 141 ~ 154
Goteri G / 2011 / BCL6 and human germinal center-associated lymphoma(HGAL)in follicular lymphomas / Diagn Pathol 6 : 97 ~
Borovecki A / 2008 / Prognostic significance of B-cell differentiation genes encoding proteins in diffuse large B-cell lymphoma and follicular lymphoma grade 3 / Croat Med J
Eshoa C / 2001 / Decreased CD10 expression in grade III and in interfollicular infiltrates of follicular lymphomas / Am J Clin Pathol 115 : 862 ~ 867
Flanders KC / 2001 / Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo : signaling by BMPs and TGF-betas / Dev Dyn 220 : 141 ~ 154
Goteri G / 2011 / BCL6 and human germinal center-associated lymphoma(HGAL)in follicular lymphomas / Diagn Pathol 6 : 97 ~
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