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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제49권 제1호
- 발행연도
- 2015.1
- 수록면
- 44 - 51 (8page)
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Background: Meningiomas show high recurrence rates even after curative tumor removal. The invasiveness of meningiomas may contribute to their high recurrence rates. Recently, c-MET and hepatocyte growth factor (HGF) have been reported to be involved in cancer invasion. Methods: We examined the immunohistochemical expression of c-MET and HGF in 100 cases of patientswith meningiomas who have undergone complete tumor removal. Results: c-MET-High and HGFHigh were found in 17% and 13% of meningiomas, respectively. Brain invasion was observed in 17.6% of c-MET-High meningiomas, but in only 2.4% of c-MET-Low meningiomas (p=.033). Bone/soft tissue invasion was observed in 23.5% of c-MET-High meningiomas and in 9.6% of c-MET-Lowmeningiomas (p=.119). HGF-High did not show statistical association with brain invasion or bone/soft tissue invasion. c-MET-High demonstrated shorter recurrence-free survival (RFS, 93.5±8.2 months vs 96.1±1.9 months); however, this difference was not statistically significant (p=.139). There was no association of HGF-High with RFS. Conclusions: This study demonstrates that c-MET-High is associated with brain invasion of meningiomas, and that c-MET expression may be a useful predictive marker for meningioma recurrence. Patients with invasive meningiomas with high expressions of c-MET may be good candidates for targeted therapy using c-MET inhibitors.
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참고문헌 (25)
참고문헌 신청
Alahmadi H / 2011 / Pathology and genetics of meningiomas / Semin Diagn Pathol 28 : 314 ~ 324
Barresi V / 2011 / MMP-9 expression in meningiomas: a prognostic marker for recurrence risk? / J Neurooncol 102 : 189 ~ 196
Bozkaya G / 2012 / Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis / Mol Cancer 11 : 64 ~
Caltabiano R / 2013 / Prognostic value of EGFR expression in de novo and progressed atypical and anaplastic meningiomas : an immunohistochemical and fluorescence in situ hybr
Choy W / 2011 / The molecular genetics and tumor pathogenesis of meningiomas and the future directions of meningioma treatments / Neurosurg Focus 30 : E6 ~
Barresi V / 2011 / MMP-9 expression in meningiomas: a prognostic marker for recurrence risk? / J Neurooncol 102 : 189 ~ 196
Bozkaya G / 2012 / Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis / Mol Cancer 11 : 64 ~
Caltabiano R / 2013 / Prognostic value of EGFR expression in de novo and progressed atypical and anaplastic meningiomas : an immunohistochemical and fluorescence in situ hybr
Choy W / 2011 / The molecular genetics and tumor pathogenesis of meningiomas and the future directions of meningioma treatments / Neurosurg Focus 30 : E6 ~
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