지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 333 - 343 (11page)
이용수
초록· 키워드
오류제보하기
Objective: Executive dysfunction might be an important determinant for response to pharmacotherapy in obsessive-compulsive disorder (OCD), and could be sustained independently of symptom relief. The anterior cingulate cortex (ACC) has been indicated as a potential neural correlate of executive functioning in OCD. The present study examined the brain-executive function relationships in OCD from the ACC-based resting state functional connectivity networks (rs-FCNs), which reflect information processing mechanisms during task performance.
Methods: For a total of 58 subjects [OCD, n=24; healthy controls (HCs), n=34], four subdomains of executive functioning were measured using the Rey-Osterrieth Complex Figure Test (RCFT), the Stroop Color-Word Test (SCWT), the Wisconsin Card Sorting Test (WCST), and the Trail Making Test part B (TMT-B). To probe for differential patterns of the brain-cognition relationship in OCD compared to HC, the ACC-centered rs-FCN were calculated using five seed regions systemically placed throughout the ACC.
Results: Significant differences between the OCD group and the HCs with respect to the WCST perseverative errors, SCWT interference scores, and TMT-B reaction times (p<0.05) were observed. Moreover, significant interactions between diagnosis×dorsal ACC [S3]- based rs-FCN strength in the right dorsolateral prefrontal cortex for RCFT organization summary scores as well as between diagnosis×perigenual ACC [S7]-based rs-FCN strength in the left frontal eye field for SCWT color-word interference scores were unveiled.
Conclusion: These network-based neural foundations for executive dysfunction in OCD could become a potential target of future treatment, which could improve global domains of functioning broader than symptomatic relief.
목차
등록된 정보가 없습니다.
참고문헌 (88)
참고문헌 신청
Inzlicht M / 2015 / Emotional foundations of cognitive control / Trends Cogn Sci 19:126~132
Phillips ML / 2003 / Neurobiology of emotion perception I : the neural basis of normal emotion perception / Biol Psychiatry 54:504~514
Fair DA / 2007 / Development of distinct control networks through segregation and integration / Proc Natl Acad Sci U S A 104:13507~13512
Beucke JC / 2013 / Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder / JAMA Psychiatry 70:619~629
Harrison BJ / 2009 / Altered corticostriatal functional connectivity in obsessive-compulsive disorder / Arch Gen Psychiatry 66:1189~1200
Phillips ML / 2003 / Neurobiology of emotion perception I : the neural basis of normal emotion perception / Biol Psychiatry 54:504~514
Fair DA / 2007 / Development of distinct control networks through segregation and integration / Proc Natl Acad Sci U S A 104:13507~13512
Beucke JC / 2013 / Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder / JAMA Psychiatry 70:619~629
Harrison BJ / 2009 / Altered corticostriatal functional connectivity in obsessive-compulsive disorder / Arch Gen Psychiatry 66:1189~1200
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