지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 169 - 173 (5page)
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초록· 키워드
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Objective Benzodiazepines are from the most common drugs which are used for treatment of anxiety disorders. There are other drugs with antianxiety properties including antihistamines such as hydroxyzine, too. Body of evidence show that co-administration of two drugs which act through different mechanisms, makes the dose of each drug to be reduced, while preserving the desired effect with less adverse drug reactions. The aim of this study was to see whether co-administration of subeffective antianxiety doses of diazepam and hydroxyzine has any antianxiety effect in elevated zero-maze (EZM) in mice.
Methods To find the highest subeffective dose of each drug, different doses of hydroxyzine from 1.5 to 24 mg/kg and diazepam in doses of 0.25, 0.5 and 1 mg/kg were injected to male mice. Thirty minutes later, the animals were placed on EZM and various parameters of an-xiety were recorded by a camera to assess later. After determination of subeffective antianxiety dose of the drugs, co-administration of hydroxyzine and diazepam was done and the anxiety parameters were measured.
Results In co-administration of 0.25 mg/kg of diazepam and 12 mg/kg hydroxyzine, as subeffective antianxiety doses of either drug, there were not any significant differences in main anxiety parameters, i.e., time spent in open areas and open area entries compared to control group. Hence, no anxiolytic effect was seen.
Conclusion It seems that subeffective doses of diazepam and hydroxyzine may not have any facilitating or synergistic effect on each other in antianxiety responses in mice.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Baldessarini RJ / 2006 / Drug Therapy of Depression and Anxiety Disorders, in Goodman and Gilman’s the Pharmacological Basis of Therapeutics / McGraw-Hill : 429 ~ 459
Belzung C / 1997 / Naloxone potentiates the effects of subeffective doses of anxiolytic agents in mice / Eur J Pharmacol 323 : 133 ~ 136
Consoli D / 2007 / Behavioral effects of the β3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs / Eur J Pharma
Frances H / 1989 / Isolation-induced social behavioral deficit test: effect of tranquillizing drugs / Pharmacol Biochem Behav 34 : 293 ~ 296
Gladney M / 1994 / Anxiolytic activity of chloral hydrate and hydroxyzine / Pediatr Dent 16 : 183 ~ 189
Belzung C / 1997 / Naloxone potentiates the effects of subeffective doses of anxiolytic agents in mice / Eur J Pharmacol 323 : 133 ~ 136
Consoli D / 2007 / Behavioral effects of the β3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs / Eur J Pharma
Frances H / 1989 / Isolation-induced social behavioral deficit test: effect of tranquillizing drugs / Pharmacol Biochem Behav 34 : 293 ~ 296
Gladney M / 1994 / Anxiolytic activity of chloral hydrate and hydroxyzine / Pediatr Dent 16 : 183 ~ 189
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