지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 136 - 141 (6page)
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초록· 키워드
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ObjectiveaaThe serotonin transporter (5-HTT) genes are major candidate genes for modulating the suicidal behavior. We investigated the association between serotonin transporter polymorphisms and suicidal behavior in patients with major depressive disorder (MDD).
MethodsaaSerotonin transporter intron 2 VNTR polymorphism (5-HTTVNTR) and serotonin transporter linked polymorphic region polymorphism (5-HTTLPR) were analyzed in 132 depressed patients with suicidal attempt as well as in 122 normal controls. Hamilton’s 17-item Depression Rating Scale (HDRS), the Risk-Rescue rating system (RRR) and the Lethality Suicide Attempt Rating Scale updated (LSARS-II) were assessed for the depressed patients.
ResultsaaAlthough not statistically significant, a trend was found such that the 10/10 and 10/12 alleles of 5-HTTVNTR were more common in suicidal subjects than in control subjects. Comparing allele frequency, those with a 10 allele or 10 allele carriers were higher in suicidal subjects than in control subjects. No difference was noted in 5-HTTLPR genotypes and haplotype distribution between the suicidal subjects and control subjects. The RRR scores in subjects with the 10/10 5-HTTVNTR genotype or 10 5-HTTVNTR allele were significantly lower than those in subjects with other genotypes.
ConclusionaaThese results show the possibility that 10 allele of 5-HTTVNTR is related to suicidal behavior in the suicidal subjects with MDD and suggest that 12 allele of 5-HTTVNTR might be related to more lethality in the suicidal subjects with MDD.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Berman AL / 2003 / The LSARS-II: Lethality of Suicide Attempt Rating Scale-Updated / Suicide L
Bonnet-Brilhault F / 1997 / Serotonin transporter gene polymorphism and schizophrenia: an association study / Biol Psychiatry 42 : 634 ~ 636
Collier DA / 1996 / A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders / Mol Psych
Gaysina D / 2006 / The serotonin transporter gene: polymorphism and haplotype analysis in Russian suicide attempters / Neuropsychobiology 54 : 70 ~ 74
Greenberg BD / 1999 / Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets / Am J Med Genet 88 : 83 ~ 87
Bonnet-Brilhault F / 1997 / Serotonin transporter gene polymorphism and schizophrenia: an association study / Biol Psychiatry 42 : 634 ~ 636
Collier DA / 1996 / A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders / Mol Psych
Gaysina D / 2006 / The serotonin transporter gene: polymorphism and haplotype analysis in Russian suicide attempters / Neuropsychobiology 54 : 70 ~ 74
Greenberg BD / 1999 / Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets / Am J Med Genet 88 : 83 ~ 87
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