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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,293 - 1,301 (9page)
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Purpose The purpose of this study is to evaluate the effect of diabetes mellitus (DM) and preoperative glycemic control on prognosis in Korean patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy (RNU).
Materials and Methods A total of 566 patients who underwent RNU at six institutions between 2004 and 2014 were reviewed retrospectively. Kaplan-Meier and Cox regression analyses were performed to assess the association between DM, preoperative glycemic control, and recurrence-free, cancer-specific, and overall survival.
Results The median follow-up period was 33.8 months (interquartile range, 41.4 months). A total of 135 patients (23.8%) had DM and 67 patients (11.8%) had poor preoperative glycemic control. Patients with poor preoperative glycemic control had significantly shorter median recurrence-free, cancer-specific, and overall survival than patients with good preoperative glycemic control and non-diabetics (all, p=0.001). In multivariable Cox regression analysis, DM with poor preoperative glycemic control showed association with worse recurrence-free survival (hazard ratio [HR], 2.26; 95% confidence interval [CI], 1.31 to 3.90; p=0.003), cancer-specific survival (HR, 2.96; 95% CI, 1.80 to 4.87; p=0.001), and overall survival (HR, 2.13; 95% CI, 1.40 to 3.22; p=0.001).
Conclusion Diabetic UTUC patients with poor preoperative glycemic control had significantly worse oncologic outcomes than diabetic UTUC patients with good preoperative glycemic control and non-diabetics. Further investigation is needed to elucidate the exact mechanism underlying the impact of glycemic control on UTUC treatment outcome.
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참고문헌 (25)
참고문헌 신청
Dankner R / 2012 / Diabetes, glucose control, glucose lowering medications, and cancer risk : a 10-year populationbased historical cohort / BMC Cancer 12:364
Green DA / 2013 / Urothelial carcinoma of the bladder and the upper tract : disparate twins / J Urol 189:1214~1221
Campbell PT / 2012 / Diabetes and cause-specific mortality in a prospective cohort of one million U.S. adults / Diabetes Care 35:1835~1844
Barone BB / 2008 / Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus : a systematic review and meta-analysis / JAMA 300:2754~2764
Hwang EC / 2011 / Impact of diabetes mellitus on recurrence and progression in patients with non-muscle invasive bladder carcinoma: a retrospective cohort study / Int J Urol 18:769~776
Green DA / 2013 / Urothelial carcinoma of the bladder and the upper tract : disparate twins / J Urol 189:1214~1221
Campbell PT / 2012 / Diabetes and cause-specific mortality in a prospective cohort of one million U.S. adults / Diabetes Care 35:1835~1844
Barone BB / 2008 / Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus : a systematic review and meta-analysis / JAMA 300:2754~2764
Hwang EC / 2011 / Impact of diabetes mellitus on recurrence and progression in patients with non-muscle invasive bladder carcinoma: a retrospective cohort study / Int J Urol 18:769~776
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