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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: Epidemiological studies have reported that vitamin D deficiency is associated with inflammatory disease. Smoking is a well-known risk factor for inflammation. However, few studies have investigated the interactive effect of vitamin D deficiency and smoking on inflammation. This study aims to investigate the interaction of vitamin D and smoking with inflammatory markers in the urban elderly.
Methods: We used data from the Korean Elderly Environmental Panel Study, which began in August 2008 and ended in August 2010, and included 560 Koreans ≥60 years old living in Seoul. Data was collected via questionnaires that included items about smoking status at the first visit. Vitamin D levels, high-sensitivity C-reactive protein (hs-CRP), and white blood cell (WBC) counts were repeatedly measured up to three times.
Results: The association of vitamin D and hs-CRP was significant after adjusting for known confounders (β=-0.080, p=0.041). After separate analysis by smoking status, the association of vitamin D deficiency and hs-CRP in smokers was stronger than that in nonsmokers (smokers: β=-0.375, p=0.013; non-smokers: β=-0.060, p=0.150). Smoking status was an effect modifier that changed the association between vitamin D deficiency and hs-CRP (interaction estimate: β=-0.254, p=0.032). Vitamin D was not significantly associated with WBC count (β=0.003, p=0.805).
Conclusions: Vitamin D deficiency was associated with hs-CRP in the urban elderly. Smoking status was an effect modifier of this association.
Vitamin D deficiency was not significantly associated with WBC count.
목차
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참고문헌 (37)
참고문헌 신청
Forrest KY / 2011 / Prevalence and correlates of vitamin D deficiency in US adults / Nutr Res 31(1):48~54
Holick MF / 2003 / Vitamin D: a millenium perspective / J Cell Biochem 88(2):296~307
Holick MF / 1994 / McCollum Award Lecture, 1994: vitamin D--new horizons for the 21st century / Am J Clin Nutr 60(4):619~630
Wang TJ / 2008 / Vitamin D deficiency and risk of cardiovascular disease / Circulation 117(4):503~511
Roy A / 2015 / Independent association of severe vitamin D deficiency as a risk of acute myocardial infarction in Indians / Indian Heart J 67(1):27~32
Holick MF / 2003 / Vitamin D: a millenium perspective / J Cell Biochem 88(2):296~307
Holick MF / 1994 / McCollum Award Lecture, 1994: vitamin D--new horizons for the 21st century / Am J Clin Nutr 60(4):619~630
Wang TJ / 2008 / Vitamin D deficiency and risk of cardiovascular disease / Circulation 117(4):503~511
Roy A / 2015 / Independent association of severe vitamin D deficiency as a risk of acute myocardial infarction in Indians / Indian Heart J 67(1):27~32
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