지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 413 - 425 (13page)
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The Philadelphia chromosome was the first genetic abnormality discovered in cancer (in 1960), and it was found to be consistently associated with CML. The description of the Philadelphia chromosome ushered in a new era in the field of cancer cytogenetics. Accu- mulating genetic data have been shown to be intimately associated with the diagnosis and prognosis of neoplasms; thus, karyotyping is now considered a mandatory investigation for all newly diagnosed leukemias. The development of FISH in the 1980s overcame many of the drawbacks of assessing the genetic alterations in cancer cells by karyotyping. Karyo- typing of cancer cells remains the gold standard since it provides a global analysis of the abnormalities in the entire genome of a single cell. However, subsequent methodological advances in molecular cytogenetics based on the principle of FISH that were initiated in the early 1990s have greatly enhanced the efficiency and accuracy of karyotype analysis by marrying conventional cytogenetics with molecular technologies. In this review, the de- velopment, current utilization, and technical pitfalls of both the conventional and molecu- lar cytogenetics approaches used for cancer diagnosis over the past five decades will be discussed.
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참고문헌 (90)
참고문헌 신청
Au WY / 2002 / Subvalvular pulmonary stenosis, demyelination and myelodysplasia with monosomy 7 / Leuk Lymphoma 43:1505~1507
Au WY / 2012 / Sequential chronic myelogenous leukemia, B-lineage lymphoma and erythroleukemia with monosomy 7 over 10 years / Leuk Lymphoma 53:733~735
Surapolchai P / 2013 / Central diabetes insipidus: an unusual complication in a child with juvenile myelomonocytic leukemia and monosomy 7 / J Pediatr Hematol Oncol 35:84~87
Wan TS / 2003 / Deletion 9q as the sole karyotypic abnormality in myelocytic disorders: a new case of myelodysplastic syndrome and its prognostic implications in acute myelocytic leukemia / Cancer Genet Cytogenet 145:184~186
Wan TS / 1999 / Complex variant 15;17 translocations in acute promyelocytic leukemia. A case report and review of three-way translocations / Cancer Genet Cytogenet 111:139~143
Au WY / 2012 / Sequential chronic myelogenous leukemia, B-lineage lymphoma and erythroleukemia with monosomy 7 over 10 years / Leuk Lymphoma 53:733~735
Surapolchai P / 2013 / Central diabetes insipidus: an unusual complication in a child with juvenile myelomonocytic leukemia and monosomy 7 / J Pediatr Hematol Oncol 35:84~87
Wan TS / 2003 / Deletion 9q as the sole karyotypic abnormality in myelocytic disorders: a new case of myelodysplastic syndrome and its prognostic implications in acute myelocytic leukemia / Cancer Genet Cytogenet 145:184~186
Wan TS / 1999 / Complex variant 15;17 translocations in acute promyelocytic leukemia. A case report and review of three-way translocations / Cancer Genet Cytogenet 111:139~143
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