지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 23 - 31 (9page)
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초록· 키워드
오류제보하기
Background: The identification of clinically meaningful specific immunoglobulin E (sIgE) is important for the diagnosis and management of allergic diseases. Various in vitro sIgE detection methods are available worldwide. Depending on the number of antigens that can be tested simultaneously, there are two representative methods: singleplex and multiplex. Singleplex sIgE detection is mainly provided by Thermo Fisher (ImmunoCAP) and Siemens (Immulite). This study aimed to compare the diagnostic agreement of two singleplex sIgE detection assays. Methods: Sera from 209 Korean patients with allergic disease were used to compare the ImmunoCAP and Immulite assays with respect to the following allergens: inhalant allergens (Dermatophagoides farinae, cat and dog dander, oak, rye grass, mugwort, Alternaria, German cockroach) and food allergens (hen’s egg white, cow’s milk, wheat, peanut, soybean, and shrimp). Data from 902 paired comparison tests were included for comparisons. Qualitative, semi-quantitative, and quantitative comparisons were performed using statistical analyses. Results: In qualitative comparisons, the positivity and negativity agreements ranged from 75% (wheat, shrimp) to 96% (Alternaria). Class consistency (classes 0–6) was well matched. Spearman’s rank correlation coefficients for all allergens except shrimp were over 0.7. In quantitative comparisons, all allergens excluding shrimp showed >0.7 intra-class correlation coefficients. Conclusions: The ImmunoCAP and Immulite systems showed similar performances. However, clinicians should consider fundamental methodological differences between the assays.
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참고문헌 (23)
참고문헌 신청
박경희 / 2017 / Comparison of the ImmunoCAP Assay and AdvanSureTM AlloScreen Advanced Multiplex Specific IgE Detection Assay / Yonsei Medical Journal 58(4):786~792
이재현 / 2015 / Performance of the PROTIATM Allergy-Q® System in the Detection of Allergen-specific IgE: A Comparison With the ImmunoCAP® System / Allergy, Asthma & Immunology Research 7(6):565~572
Bousquet J / 2012 / Practical guide to skin prick tests in allergy to aeroallergens / Allergy 67:18~24
Celik-Bilgili S / 2005 / The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges / Clin Exp Allergy 35:268~273
Williams PB / 2000 / Analytic precision and accuracy of commercial immunoassays for specific IgE: Establishing a standard / J Allergy Clin Immunol 105:1221~1230
이재현 / 2015 / Performance of the PROTIATM Allergy-Q® System in the Detection of Allergen-specific IgE: A Comparison With the ImmunoCAP® System / Allergy, Asthma & Immunology Research 7(6):565~572
Bousquet J / 2012 / Practical guide to skin prick tests in allergy to aeroallergens / Allergy 67:18~24
Celik-Bilgili S / 2005 / The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges / Clin Exp Allergy 35:268~273
Williams PB / 2000 / Analytic precision and accuracy of commercial immunoassays for specific IgE: Establishing a standard / J Allergy Clin Immunol 105:1221~1230
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