지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 56 - 65 (10page)
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초록· 키워드
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Objective To investigate the impact of vascular factors on the electrophysiologic severity of diabetic neuropathy (DPN).Methods Total 530 patients with type 2 diabetes were enrolled retrospectively. We rated severity of DPN from 1 (normal) to 4 (severe) based on electrophysiologic findings. We collected the data concerning vascular factors (including brachial-ankle pulse wave velocity [PWV], ankle brachial index, ultrasound of carotid artery, lipid profile from the blood test, and microalbuminuria [MU] within 24 hours urine), and metabolic factors of diabetes (such as glycated hemoglobin [HbA1c]). We analyzed the differences among the four subgroups using 2 test and ANOVA, and ordinal logistic regression analysis was performed to investigate the relationship between significant variables and severity of DPN.Results The severity of DPN was significantly associated with duration of diabetes, HbA1c, existence of diabetic retinopathy and nephropathy, PWV, presence of plaque, low density lipoprotein-cholesterol and MU (p<0.05). Among these variables, HbA1c and presence of plaque were more significantly related with severity of DPN in logistic regression analysis (p<0.001), and presence of plaque showed the highest odds ratio (OR=2.52).Conclusion Our results suggest that markers for vascular wall properties, such as PWV and presence of plaque, are significantly associated with the severity of DPN. The presence of plaque was more strongly associated with the severity of DPN than other variables.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Orchard TJ / 1990 / Prevalence of complications in IDDM by sex and duration: Pittsburgh Epidemiology of Diabetes Complications Study II / Diabetes 39:1116~1124
Maser RE / 1989 / Epidemiological correlates of diabetic neuropathy: report from Pittsburgh Epidemiology of Diabetes Complications Study / Diabetes 38:1456~1461
The Diabetes Control and Complications Trial Research Group / 1995 / The effect of intensive diabetes therapy on the development and progression of neuropathy / Ann Intern Med 122:561~568
박근영 / 2006 / 말초 혈관 질환이 당뇨병성 신경병증에 미치는 영향 / Annals of Rehabilitation Medicine 30(1):25~32
Pyorala K / 1987 / Diabetes and atherosclerosis:an epidemiologic view / Diabetes Metab Rev 3:463~524
Maser RE / 1989 / Epidemiological correlates of diabetic neuropathy: report from Pittsburgh Epidemiology of Diabetes Complications Study / Diabetes 38:1456~1461
The Diabetes Control and Complications Trial Research Group / 1995 / The effect of intensive diabetes therapy on the development and progression of neuropathy / Ann Intern Med 122:561~568
박근영 / 2006 / 말초 혈관 질환이 당뇨병성 신경병증에 미치는 영향 / Annals of Rehabilitation Medicine 30(1):25~32
Pyorala K / 1987 / Diabetes and atherosclerosis:an epidemiologic view / Diabetes Metab Rev 3:463~524
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