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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 624 - 636 (13page)
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초록· 키워드
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Objectives: The purpose of this study was to investigate the cardioprotective effect of the potent antioxidant properties of Scrophulariae Radix (SR) aqueous extracts by examining pressure overload (PO) heart failure (HF) induced by transverse aortic constriction (TAC) of C57BL/6 mice. Methods: SR (500, 250, 125 mg/kg) and resveratrol (10 mg/kg) were administered orally once a day for 14 days, after the TAC operation. Changes in mortality, the body and heart weights, histopathology of the heart, and antioxidant defense system of the heart were analyzed. Results: After the TAC operation, increases were observed in mortality, heart weights, left ventricular hypertrophy, and lytic and focal fibrotic histological change, and destruction of the heart antioxidant defense system. However, the HF signs showed dose-dependent inhibition following 14 days of continuous oral treatment with SR. A SR dose of 125 mg/kg gave a similar inhibition to that obtained with resveratrol at 10 mg/kg. Conclusions: Oral administration of SR beneficially improves PO-induced HF following TAC surgery by increasing the activity of the heart antioxidant defense system. The overall effect of SR at 125 mg/kg is similar to the effect of resveratrol at 10 mg/kg. However, more detailed mechanistic studies should be performed by screening of the biologically active compounds in SR.
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참고문헌 (31)
참고문헌 신청
Juric D / 2007 / Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol / Am J Physiol Heart Circ Physiol 292(5):H2138~H2143
Gupta PK / 2014 / Protective effect of resveratrol against pressure overloadinduced heart failure / Food Sci Nutr 2(3):218~229
Movahed A / 2012 / Resveratrol protects adult cardiomyocytes against oxidative stress mediated cell injury / Arch Biochem Biophys 527(2):74~80
Qi J / 2014 / Apocynum tablet protects against cardiac hypertrophy via inhibiting AKT and ERK1/2 phosphorylation after pressure overload / Evid Based Complement Alternat Med 2014:769515
Wojciechowski P / 2010 / Resveratrol arrests and regresses the development of pressure overloadbut not volume overload-induced cardiac hypertrophy in rats / J Nutr 140(5):962~968
Gupta PK / 2014 / Protective effect of resveratrol against pressure overloadinduced heart failure / Food Sci Nutr 2(3):218~229
Movahed A / 2012 / Resveratrol protects adult cardiomyocytes against oxidative stress mediated cell injury / Arch Biochem Biophys 527(2):74~80
Qi J / 2014 / Apocynum tablet protects against cardiac hypertrophy via inhibiting AKT and ERK1/2 phosphorylation after pressure overload / Evid Based Complement Alternat Med 2014:769515
Wojciechowski P / 2010 / Resveratrol arrests and regresses the development of pressure overloadbut not volume overload-induced cardiac hypertrophy in rats / J Nutr 140(5):962~968
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