조기 성문암 환자에서 레이저 절제술 또는 방사선 치료 후 음성학적 결과 비교

안수현; 김준현; 이수현; 김우진; 김동훈; 박영학; 이소윤

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자료유형: 학술저널

저자정보: 안수현 김준현 이수현 김우진 김동훈 박영학 이소윤

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제55권 제11호

발행연도: 2012.1

수록면: 701 - 706 (6page)

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Background and Objectives Radiotherapy and laser surgery are the main treatment modalities for early glottic cancer. However, which treatment has better voice outcome is unclear. Few studies have considered the effect of radiation dose on voice outcomes after radiotherapy. The purpose of this study was to compare voice outcomes in early glottic cancer patients between two treatment modalities and to identify whether radiation dose affects voice outcomes. Subjects and Method From January 1995 to December 2010, 66 patients with the early glottic cancer who underwent laser surgery (n=27) or radiotherapy (n=39) were retrospectively investigated. Voice quality was assessed using Computerized Speech Lab and F0, Jitter, Shimmer and noise to harmonic ratio were evaluated. For aerodynamic test, maximum phonation time was also evaluated. Results F0 differed statistically between the laser surgery group and radiotherapy group. In laser surgery group, F0 was elevated after surgery. On the other hand, F0 decreased statistically after radiotherapy. In the radiotherapy group, the dose was statistically different between the lower and higher dose groups. In T2 stage disease, which received a higher radiation dose, voice outcomes were poorer than in T1a or T1b stage diseases. Conclusion In early glottic cancer, F0 differed statistically between the laser surgery group and the radiotherapy group: F0 decreased statistically after radiotherapy. In the radiotherapy group, voice quality was affected by radiation dose as the higher dose resulted in poorer voice outcomes.

#Early glottic cancer #Laser surgery #Radiation dose #Radiotherapy #Voice

참고문헌 (21)

참고문헌 신청

Chen MF / 2003 / Radiotherapy of early-stage glottic cancer: analysis of factors affecting prognosis / Ann Otol Rhinol Laryngol 112 (10) : 904 ~ 911

Higgins KM / 2009 / Treatment of early-stage glottic cancer: meta-analysis comparison of laser excision versus radiotherapy / J Otolaryngol Head Neck Surg 38 (6) : 603 ~ 612

Jotic A / 2012 / Voice quality after treatment of early glottic carcinoma / J Voice 26 (3) : 381 ~ 389

Ledda GP / 2006 / Functional outcomes after CO2 laser treatment of early glottic carcinoma / Laryngoscope 116 (6) : 1007 ~ 1011

Lee JC / 2008 / Comparison of functional voice outcomes in patients treated with laser surgery and radiation therapy for early glottic cancer / J Korean Soc Logop Phoniatr 1