지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 116 - 124 (9page)
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초록· 키워드
오류제보하기
Acute kidney injury (AKI) can result in mortality or progress to chronic kidney disease in hospitalized patients. Although serum creatinine has long been used as the best biomarker for diagnosis of AKI, it has some clinical limitations, especially in children. New biomarkers are needed for early diagnosis, differential diagnosis, and reliable prediction of prognosis in AKI. Up to the present, candidate AKI biomarkers include neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), liver- type fatty acid-binding protein (L-FABP), matrix metalloproteinase-9 (MMP-9), and N- acetyl-ß-D-glucosaminidase (NAG). However, whether these are superior to serum creatinine in the confirmation of diagnosis and prediction of prognosis in AKI is unclear. Further studies are needed for clinical application of these new biomarkers in AKI.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Akcan-Arikan A / 2007 / Modified RIFLE criteria in critically ill children with acute kidney injury / Kidney Int 71 : 1028 ~ 1035
Al-Ismaili Z / 2011 / Biomarkers of acute kidney injury in children:discovery, evaluation, and clinical application / Pediatr Nephrol 26 : 29 ~ 40
Bennett M / 2008 / Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study / Clin J Am Soc Nephrol 3 : 665 ~ 673
Biomarkers Definitions Working Group / 2001 / Biomarkers and surrogate endpoints: preferred definitions and conceptual framework / Clin Pharmacol Ther 69 : 89 ~ 95
Coca SG / 2008 / Urinary biomarkers for acute kidney injury: perspectives on translation / Clin J Am Soc Nephrol 3 : 481 ~ 490
Al-Ismaili Z / 2011 / Biomarkers of acute kidney injury in children:discovery, evaluation, and clinical application / Pediatr Nephrol 26 : 29 ~ 40
Bennett M / 2008 / Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study / Clin J Am Soc Nephrol 3 : 665 ~ 673
Biomarkers Definitions Working Group / 2001 / Biomarkers and surrogate endpoints: preferred definitions and conceptual framework / Clin Pharmacol Ther 69 : 89 ~ 95
Coca SG / 2008 / Urinary biomarkers for acute kidney injury: perspectives on translation / Clin J Am Soc Nephrol 3 : 481 ~ 490
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