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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 590 - 593 (4page)
이용수
초록· 키워드
오류제보하기
Purpose: Diffusion tensor imaging provides better understanding of pathophysiology of congenital anomalies, involving central nervous system. This study was aimed to specify the pathogenetic mechanism of heterotopia, proved by diffusion tensor imaging, and establish new findings of heterotopia on fractional anisotropy maps. Materials and Methods: Diffusion-weighted imaging data from 11patients (M : F = 7 : 4, aged from 1 to 22 years, mean = 12.3 years) who visited the epilepsy clinic and received a routine seizure protocol MRI exam were retrospectively analyzed. Fractional anisotropy (FA) maps were generated from diffusion tensor imaging of 11 patients with heterotopia. Regions of interests (ROI) were placed in cerebral cortex, heterotopic gray matter and deep gray matter, including putamen. ANOVA analysis was performed for comparison of different gray matter tissues. Results: Heterotopic gray matter showed signal intensities similar to normal gray matter on T1 and T2 weighted MRI. The measured FA of heterotopic gray matter was higher than that of cortical gray matter (0.236 ± 0.011vs. 0.169 ± 0.015, p < 0.01, one way ANOVA), and slightly lower than that of deep gray matter (0.236 ± 0.011 vs. 0.259 ± 0.016, p < 0.01). Conclusion: Increased FA of heterotopic gray matter suggests arrested neuron during radial migration and provides better understanding of neurodevelopment.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Barkovich AJ / 2000 / Morphologic characteristics of subcortical heterotopia:MR imaging study / AJNR Am J Neuroradiol 21 : 290 ~ 295
Bauer J / 1994 / Band heterotopia: a rare cause of generalized epileptic seizures / Seizure 3 : 153 ~ 155
Bourgeois JA / 1992 / A case of subcortical grey matter heterotopia presenting as bipolar disorder / Compr Psychiatry 33 : 407 ~ 410
Castillo M / 1993 / Proton MR spectroscopic characteristics of a presumed giant subcortical heterotopia / AJNR Am J Neuroradiol 14 : 426 ~ 429
Eriksson SH / 2002 / Exploring white matter tracts in band heterotopia using diffusion tractography / Ann Neurol 52 : 327 ~ 334
Bauer J / 1994 / Band heterotopia: a rare cause of generalized epileptic seizures / Seizure 3 : 153 ~ 155
Bourgeois JA / 1992 / A case of subcortical grey matter heterotopia presenting as bipolar disorder / Compr Psychiatry 33 : 407 ~ 410
Castillo M / 1993 / Proton MR spectroscopic characteristics of a presumed giant subcortical heterotopia / AJNR Am J Neuroradiol 14 : 426 ~ 429
Eriksson SH / 2002 / Exploring white matter tracts in band heterotopia using diffusion tractography / Ann Neurol 52 : 327 ~ 334
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