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Purpose: This study investigated the effectiveness of meaning-centered psychotherapy (MCP), which is known to be a helpfulpsychotherapeutic intervention in distressing conditions, for patients with pancreatobiliary cancer. Materials and Methods: We recruited 37 patients with pancreatobiliary cancer from three university general hospitals and assessedtheir psychological characteristics. Patients who reported clinically significant emotional distress were recommended toundergo MCP. Patients who consented to MCP were provided four sessions of the therapy. Patient psychological characteristicswere assessed again 2 months after MCP. For statistical comparison, outcome variables included anxiety, depression, mental adjustmentto cancer, and quality of life (QoL), as well as the degree of stress and physical symptoms. Results: Sixteen patients completed the MCP and the final assessment 2 months later. In the initial assessment, the patients receivingMCP showed higher levels of anxiety and depression than those not receiving MCP, and QoL was also lower in terms ofrole function, emotional function, social function, and global QoL. At the 2-month follow-up, the MCP group showed a significantimprovement in anxiety (p=0.007), depression (p=0.010), and anxious preoccupation (p<0.001). In addition, QoL significantly improvedin the MCP group, while there was no significant change in the non-MCP group. Conclusion: In this study, MCP showed potential therapeutic benefits against emotional distress in patients with pancreatobiliarycancer, improving their QoL.

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