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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제17권 제3호
- 발행연도
- 2018.1
- 수록면
- 110 - 119 (10page)
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Background and Purpose: To analyze 18F-THK5351 positron emission tomography (PET) scans of patients with clinically diagnosed nonfluent/agrammatic variant primary progressive aphasia (navPPA). Methods: Thirty-one participants, including those with Alzheimer's disease (AD, n =13), navPPA ( n =3), and those with normal control (NC, n =15) who completed 3 Tesla magnetic resonance imaging, 18F-THK5351 PET scans, and detailed neuropsychological tests, were included. Voxel-based and region of interest (ROI)-based analyses were performed to evaluate retention of 18F-THK5351 in navPPA patients. Results: In ROI-based analysis, patients with navPPA had higher levels of THK retention in the Broca's area, bilateral inferior frontal lobes, bilateral precentral gyri, and bilateral basal ganglia. Patients with navPPA showed higher levels of THK retention in bilateral frontal lobes (mainly left side) compared than NC in voxel-wise analysis. Conclusions: In our study, THK retention in navPPA patients was mainly distributed at the frontal region which was well correlated with functional-radiological distribution of navPPA. Our results suggest that tau PET imaging could be a supportive tool for diagnosis of navPPA in combination with a clinical history.
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참고문헌 (35)
참고문헌 신청
Mesulam MM / 2003 / Primary progressive aphasia--a language-based dementia / N Engl J Med 349:1535~1542
Gorno-Tempini ML / 2004 / Cognition and anatomy in three variants of primary progressive aphasia / Ann Neurol 55:335~346
Josephs KA / 2006 / Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech / Brain 129:1385~1398
Hodges JR / 2004 / Clinicopathological correlates in frontotemporal dementia / Ann Neurol 56:399~406
Kertesz A / 2005 / The evolution and pathology of frontotemporal dementia / Brain 128:1996~2005
Gorno-Tempini ML / 2004 / Cognition and anatomy in three variants of primary progressive aphasia / Ann Neurol 55:335~346
Josephs KA / 2006 / Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech / Brain 129:1385~1398
Hodges JR / 2004 / Clinicopathological correlates in frontotemporal dementia / Ann Neurol 56:399~406
Kertesz A / 2005 / The evolution and pathology of frontotemporal dementia / Brain 128:1996~2005
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