지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: The aim of this study was to evaluate the longitudinal changes of trabecular bone score (TBS) during and after bisphosphonate (BP) treatment in postmenopausal Korean women with osteoporosis. Methods: We analyzed 191 patients who took BP and underwent bone mineral density (BMD) test for the period from January 2010 to December 2015. The mean follow up period during treatment and after treatment was 22.8 months and 18 months, respectively. The TBS and BMD values were evaluated by the percent changes relative to the baseline. Results: In 191 patients, who treated with BPs, L-spine BMD increased 3.65±0.5% and TBS increased 0.26±0.4% from baseline during first 1 year. At 2 to 4 year, the changes of BMD and TBS from baseline gradually increased up to 9.3±3.25% and 2.69±0.98% and both results showed statistically significant correlation. In 86 patients who stopped BPs, L-spine BMD decreased -0.54±1.07% and TBS increased 0.33±1.96% from baseline during 3 year follow up period. Conclusions: Lumbar spine TBS increase over time with BPs treatment although the changes were less than that of BMD. Also, it preserve for years after stopping treatment, as the changes of lumbar spine BMD. The results of BMD and TBS showed significant correlation during treatment but not during drug withdrawal.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Briot K / 2013 / Added value of trabecular bone score to bone mineral density for prediction of osteoporotic fractures in postmenopausal women: the OPUS study / Bone 57 : 23
Chen P / 2006 / Change in lumbar spine BMD and vertebral fracture risk reduction in teriparatide-treated postmenopausal women with osteoporosis / J Bone Miner Res 21 : 1785 ~
Cummings SR / 2002 / Clinical use of bone densitometry: scientific review / JAMA 288 : 1889 ~ 1897
Dufresne TE / 2003 / Risedronate preserves bone architecture in early postmenopausal women in 1 year as measured by three-dimensional microcomputed tomography / Calcif Tissu
Eastell R / 2011 / Bisphosphonates for postmenopausal osteoporosis / Bone 49 : 82 ~ 88
Chen P / 2006 / Change in lumbar spine BMD and vertebral fracture risk reduction in teriparatide-treated postmenopausal women with osteoporosis / J Bone Miner Res 21 : 1785 ~
Cummings SR / 2002 / Clinical use of bone densitometry: scientific review / JAMA 288 : 1889 ~ 1897
Dufresne TE / 2003 / Risedronate preserves bone architecture in early postmenopausal women in 1 year as measured by three-dimensional microcomputed tomography / Calcif Tissu
Eastell R / 2011 / Bisphosphonates for postmenopausal osteoporosis / Bone 49 : 82 ~ 88
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