지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 104 - 108 (5page)
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초록· 키워드
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Fine needle aspiration cytology (FNAC) of thyroid nodules is the best screening test for the selection of patients that may require surgical management. However, the diagnosis of follicular neoplasm on FNAC remains a gray area and the main differential diagnosis of follicular neoplasm includes benign (nodular hyperplasia and follicular adenoma) and malignant (follicular carcinoma and follicular variant of papillary carcinoma) lesions.
The cytologic diagnosis of follicular neoplasm is based on the high cellularity, microfollicular or trabecular pattern, overlapping follicular cells, and scanty or absent colloid. Histologically, the diagnosis of follicular carcinoma requires the presence of tumor capsular invasion or vascular invasion. In the follicular variant of papillary carcinoma, nuclear features of papillary carcinoma may be subtle and seen in only a small number of cells, and thus may not be readily appreciated. Analyses of BRAF and RAS point mutations and RET/PTC and PAX8/PPARγ rearrangements have been reported to be a useful ancillary tool for diagnosing thyroid cancer in cytology specimens. The presence of BRAF or RET/PTC mutation is a strong indicator of papillary carcinoma. PAX8/PPARγ rearrangement is exclusively found in follicular carcinoma. RAS mutations are found in follicular adenoma/carcinoma and follicular variant of papillary carcinoma. Therefore, molecular testing of FNAC samples can improve the accuracy of cytologic diagnosis.
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참고문헌 (21)
참고문헌 신청
Eszlinger M / 2010 / Molecular fine-needle aspiration biopsy diagnosis of thyroid nodules by tumor specific mutations and gene expression patterns / Mol Cell Endocrinol 322
Ferraz C / 2011 / Current state and future perspective of molecular diagnosis of fine-needle aspiration biopsy of thyroid nodules / J Clin Endocrinol Metab 96 (7) : 2016 ~ 20
Gharib H / 2010 / American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and EuropeanThyroid Association Medical Guidelines for Clinical Practi
Henry MR / 2010 / Follicular neoplasm/ suspicious for a follicular neoplasm, In The Bethesda system for reporting thyroid cytopathology : 51 ~ 58
Jung CK / 2012 / Mutational patterns and novel mutations of the BRAF gene in a large cohort of Korean patients with papillary thyroid carcinoma / Thyroid 22 (8) : 791 ~ 797
Ferraz C / 2011 / Current state and future perspective of molecular diagnosis of fine-needle aspiration biopsy of thyroid nodules / J Clin Endocrinol Metab 96 (7) : 2016 ~ 20
Gharib H / 2010 / American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and EuropeanThyroid Association Medical Guidelines for Clinical Practi
Henry MR / 2010 / Follicular neoplasm/ suspicious for a follicular neoplasm, In The Bethesda system for reporting thyroid cytopathology : 51 ~ 58
Jung CK / 2012 / Mutational patterns and novel mutations of the BRAF gene in a large cohort of Korean patients with papillary thyroid carcinoma / Thyroid 22 (8) : 791 ~ 797
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