본문 바로가기
  • 학술저널

표지

DBpia에서 서비스 중인 논문에 한하여 피인용 수가 반영됩니다. 내서재에 논문을 담은 이용자 수의 총합입니다.

발행기관의 요청으로 개인이 구매하실 수 없습니다.

초록·키워드 목차

To determine whether the PPARα agonist fenofi-brate regulates obesity and lipid metabolism with sexual dimorphism, we examined the efects of (WAT) mas, circulating lipids, and the expresion of PPARα target genes in both sexes of high fat diet-fed C57BL/6J mice. Both sexes of mice fed a high-fat diet for 14 weks exhibited increases in body weight, visceral WAT mas, as wel as serum triglycerides and cholesterol, although these ef-fects were more pronounced among males. Feed-ing a high fat diet suplemented with fenofibrate (0.05% w/w) reduced al of these effects signifi-cantly in males except serum cholesterol level. Fe-males on a fenofibrate-enriched high fat diet had ler extent compared to males, but did not exhibit decreases in body weight, WAT mas, and serum cholesterol. Fenofibrate treatment resulted in he-patic induction of PPARα target genes encoding enzymes for faty acid β-oxidation, the magnitudes of which were much higher in males compared to females, as evidenced by results for acyl-CoA oxidase, a first enzyme of the β-oxidation system. These results suggest that observed sexually di-morphic effects on body weight, WAT mass and related elements in the diferential activation of PPARα. #fenofibrate #lipid #obesity #PARα #sex

등록된 정보가 없습니다.

저자의 논문

DBpia에서 서비스 중인 논문에 한하여 피인용 수가 반영됩니다.
Insert title here
논문의 정보가 복사되었습니다.
붙여넣기 하세요.