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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 2015.1
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이 논문의 연구 히스토리 (2)
2015
PLZF-양성 선천면역 T 세포가 TGF-β 의존적인 활성화된 조절 T 세포 발달에 미치는 영향 : PLZF+ innate T cells support TGF-?-dependent generation of activated/memory-like regulatory T cells
강병현
의학과
2015.01
학위논문
Analyses of the TCR repertoire of MHC class II-restricted innate CD4+ T cells
강병현
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최보미
외 10명
Experimental and Molecular Medicine
2015.01
학술저널
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Analysis of the T-cell receptor (TCR) repertoire of innate CD4+ T cells selected by major histocompatibility complex (MHC)class II-dependent thymocyte–thymocyte (T-T) interaction (T-T CD4+ T cells) is essential for predicting the characteristics of theantigens that bind to these T cells and for distinguishing T-T CD4+ T cells from other types of innate T cells. Using the TCRmini Tg mouse model, we show that the repertoire of TCRα chains in T-T CD4+ T cells was extremely diverse, in contrast to therepertoires previously described for other types of innate T cells. The TCRα chain sequences significantly overlapped between T-T CD4+ T cells and conventional CD4+ T cells in the thymus and spleen. However, the diversity of the TCRα repertoire ofT-T CD4+ T cells seemed to be restricted compared with that of conventional CD4+ T cells. Interestingly, the frequency of the parental OT-II TCRα chains was ignificantly reduced in the process of T-T interaction. This diverse and shifted repertoire in T-T CD4+ T cells has biological relevance in terms of defense against diverse pathogens and a possible regulatory role during peripheral T-T interaction.
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참고문헌 (26)
참고문헌 신청
Barnden MJ / 1998 / Defective TCR expression in transgenic mice constructed using cDNA-based alpha-and beta-chain genes under the control of heterologous regulatory elements
Bendelac A / 2007 / The biology of NKT cells / Annu Rev Immunol 25 : 297 ~ 336
Chao A / 1992 / Estimating the number of classes via sample coverage / J Am Statist Assoc 87 : 210 ~ 217
Choi EY / 1997 / Thymocytes positively select thymocytes in human system / Hum Immunol 54 : 15 ~ 20
Choi EY / 2005 / Thymocytethymocyte interaction for efficient positive selection and maturation of CD4T cells / Immunity 23 : 387 ~ 396
Bendelac A / 2007 / The biology of NKT cells / Annu Rev Immunol 25 : 297 ~ 336
Chao A / 1992 / Estimating the number of classes via sample coverage / J Am Statist Assoc 87 : 210 ~ 217
Choi EY / 1997 / Thymocytes positively select thymocytes in human system / Hum Immunol 54 : 15 ~ 20
Choi EY / 2005 / Thymocytethymocyte interaction for efficient positive selection and maturation of CD4T cells / Immunity 23 : 387 ~ 396
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