지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 67 - 76 (10page)
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초록· 키워드
오류제보하기
Several parameters and risk factors were compared between Korean male myocardial infarction (MI) patients (n = 10) and angina pectoris (AP) patients (n = 17) to search unique biomarkers for myocardial infarction (MI) in lipoprotein level. Individual serum and lipoprotein fractions (VLDL, LDL, HDL2, HDL3) were isolated and analyzed by lipid and protein determination and enzyme assay. The MI group was found to have a 25 and 30% higher serum cholesterol and triacylglycerol (TG) level than the AP group, respectively, however, their body mass index (BMI), LDL-cholesterol (C), HDL-C, and glucose levels fell within the normal range. MI patients were found to have an approximately two-fold higher level of serum IL-6 and an 18% lower serum apoA-I level than that of the AP group. LDL and HDL2 fraction of the MI group were more enriched with TG than those of AP group. The increased TG was correlated well with the increased level of apoC-III in the same fraction. Cholesteryl ester transfer protein (CETP) activity and protein level were greatly increased in MI patients in the LDL and HDL3 fractions. MI patients showed more severely oxidized LDL fraction than patients in the AP group, as well as the weakest antioxidant ability of serum. Conclusively, MI patients were found to have unique serum and lipoprotein characteristics including increased IL-6 and TG in serum, with CETP and apoC-III in the LDL and HDL fractions, as well as severely impaired antioxidant ability of HDL.
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참고문헌 (24)
참고문헌 신청
[학술지
Asia pacific cohort studies collaboration / 2004 / Serum triglycerides as a risk factor for cardiovascular diseases in the asia-pacific region / Circulation 110 : 2678 ~ 86
Austin MA / 1988 / Low-density lipoprotein subclass patterns and risk of myocardial infarction / J Am Med Assoc 260 : 1917 ~ 21
Ballantyne CM / 2004 / Lipoprotein-Associated Phospholipase A2, High-Sensitivity C-Reactive Protein, and Risk for Incident Coronary Heart Disease in Middle-Aged Men and Women
Benzie IF / 1996 / The ferric reducing ability of plasma(FRAP) as a measure of "antioxidant power": the FRAP assay / Anal Biochem 239 : 70 ~ 6
Asia pacific cohort studies collaboration / 2004 / Serum triglycerides as a risk factor for cardiovascular diseases in the asia-pacific region / Circulation 110 : 2678 ~ 86
Austin MA / 1988 / Low-density lipoprotein subclass patterns and risk of myocardial infarction / J Am Med Assoc 260 : 1917 ~ 21
Ballantyne CM / 2004 / Lipoprotein-Associated Phospholipase A2, High-Sensitivity C-Reactive Protein, and Risk for Incident Coronary Heart Disease in Middle-Aged Men and Women
Benzie IF / 1996 / The ferric reducing ability of plasma(FRAP) as a measure of "antioxidant power": the FRAP assay / Anal Biochem 239 : 70 ~ 6
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